Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 99197..99690 | Replicon | chromosome |
Accession | NZ_CP034842 | ||
Organism | Fusobacterium necrophorum subsp. necrophorum strain ATCC 25286 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A654S0Z3 |
Locus tag | EO219_RS00510 | Protein ID | WP_035934308.1 |
Coordinates | 99424..99690 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | J5W0H3 |
Locus tag | EO219_RS00505 | Protein ID | WP_005955951.1 |
Coordinates | 99197..99427 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EO219_RS00480 | 94438..94749 | - | 312 | WP_005955931.1 | 50S ribosomal protein L21 | - |
EO219_RS00485 | 94874..96541 | - | 1668 | WP_035934298.1 | tetratricopeptide repeat protein | - |
EO219_RS00490 | 96584..97060 | - | 477 | WP_035901061.1 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | - |
EO219_RS00495 | 97076..98050 | - | 975 | WP_074517958.1 | D-glycero-beta-D-manno-heptose-7-phosphate kinase | - |
EO219_RS00500 | 98176..98694 | - | 519 | WP_005957007.1 | cob(I)yrinic acid a,c-diamide adenosyltransferase | - |
EO219_RS00505 | 99197..99427 | + | 231 | WP_005955951.1 | hypothetical protein | Antitoxin |
EO219_RS00510 | 99424..99690 | + | 267 | WP_035934308.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
EO219_RS00520 | 100402..101703 | + | 1302 | WP_035934311.1 | MATE family efflux transporter | - |
EO219_RS00525 | 101735..102484 | + | 750 | WP_035934312.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
EO219_RS00530 | 102526..104568 | + | 2043 | WP_035934313.1 | ATP-dependent DNA helicase RecG | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10578.46 Da Isoelectric Point: 10.0801
>T116918 WP_035934308.1 NZ_CP034842:99424-99690 [Fusobacterium necrophorum subsp. necrophorum]
MKYRMEFSQQGKKELKKLDAFTQKIIMKWICKNLIDTENPTIHGKELKGNLKCFWRYRVGNYRLLADIQDETVTILSIKI
GHRKEIYE
MKYRMEFSQQGKKELKKLDAFTQKIIMKWICKNLIDTENPTIHGKELKGNLKCFWRYRVGNYRLLADIQDETVTILSIKI
GHRKEIYE
Download Length: 267 bp
>T116918 NZ_CP034842:99424-99690 [Fusobacterium necrophorum subsp. necrophorum]
ATGAAATACCGAATGGAATTTTCACAACAAGGAAAAAAGGAATTGAAAAAATTAGATGCCTTTACTCAAAAAATTATTAT
GAAGTGGATCTGTAAAAATCTAATTGATACGGAAAATCCAACAATACATGGAAAAGAACTAAAGGGAAACTTAAAGTGCT
TTTGGCGTTATCGTGTCGGAAATTACAGGTTATTAGCCGATATTCAAGACGAAACGGTAACCATTTTATCAATCAAAATA
GGACACAGAAAAGAAATTTATGAGTAA
ATGAAATACCGAATGGAATTTTCACAACAAGGAAAAAAGGAATTGAAAAAATTAGATGCCTTTACTCAAAAAATTATTAT
GAAGTGGATCTGTAAAAATCTAATTGATACGGAAAATCCAACAATACATGGAAAAGAACTAAAGGGAAACTTAAAGTGCT
TTTGGCGTTATCGTGTCGGAAATTACAGGTTATTAGCCGATATTCAAGACGAAACGGTAACCATTTTATCAATCAAAATA
GGACACAGAAAAGAAATTTATGAGTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 9012.25 Da Isoelectric Point: 4.3363
>AT116918 WP_005955951.1 NZ_CP034842:99197-99427 [Fusobacterium necrophorum subsp. necrophorum]
MSIISLRLNEKEEKLLREFSAFEGLGISSYIKKIIYERLEDEYDIKCFDKAYQEYLESGKKSYSFDEVLNELGIEL
MSIISLRLNEKEEKLLREFSAFEGLGISSYIKKIIYERLEDEYDIKCFDKAYQEYLESGKKSYSFDEVLNELGIEL
Download Length: 231 bp
>AT116918 NZ_CP034842:99197-99427 [Fusobacterium necrophorum subsp. necrophorum]
ATGTCTATTATTTCTTTACGACTAAATGAAAAAGAAGAAAAATTATTAAGAGAATTCTCAGCATTTGAGGGCTTGGGAAT
CTCCTCATATATCAAAAAAATTATCTATGAAAGATTAGAGGATGAGTATGATATTAAATGTTTTGATAAAGCATATCAGG
AATATCTGGAAAGTGGAAAAAAATCATATTCTTTTGATGAAGTTTTAAATGAATTGGGAATTGAGCTATGA
ATGTCTATTATTTCTTTACGACTAAATGAAAAAGAAGAAAAATTATTAAGAGAATTCTCAGCATTTGAGGGCTTGGGAAT
CTCCTCATATATCAAAAAAATTATCTATGAAAGATTAGAGGATGAGTATGATATTAAATGTTTTGATAAAGCATATCAGG
AATATCTGGAAAGTGGAAAAAAATCATATTCTTTTGATGAAGTTTTAAATGAATTGGGAATTGAGCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A654S0Z3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | J5W0H3 |