Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/couple_hipB(antitoxin)
Location 274116..274662 Replicon plasmid pKM12v2
Accession NZ_CP034839
Organism Rahnella aquatilis strain KM25

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EJP79_RS25040 Protein ID WP_205963719.1
Coordinates 274116..274361 (-) Length 82 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EJP79_RS23775 Protein ID WP_121019978.1
Coordinates 274366..274662 (-) Length 99 a.a.

Genomic Context

EJP79_RS23750EJP79_RS23755EJP79_RS23760EJP79_RS23765EJP79_RS23780EJP79_RS23790EJP79_RS25035EJP79_RS25040EJP79_RS23775EJP79_RS23785EJP79_RS23795
Location: 269345..271444 (2100 bp)
Type: Others
Protein ID: WP_119262374.1
Location: 271458..272198 (741 bp)
Type: Others
Protein ID: WP_165497368.1
Location: 272269..273009 (741 bp)
Type: Others
Protein ID: WP_162906109.1
Location: 273405..273821 (417 bp)
Type: Others
Protein ID: WP_166861180.1
Location: 274850..275560 (711 bp)
Type: Others
Protein ID: WP_013577982.1
Location: 277095..278495 (1401 bp)
Type: Others
Protein ID: WP_014416613.1
Location: 273929..274183 (255 bp)
Type: Others
Protein ID: WP_205963718.1
Location: 274116..274361 (246 bp)
Type: Toxin
Protein ID: WP_205963719.1
Location: 274366..274662 (297 bp)
Type: Antitoxin
Protein ID: WP_121019978.1
Location: 275571..276770 (1200 bp)
Type: Others
Protein ID: WP_013577983.1
Location: 278502..279374 (873 bp)
Type: Others
Protein ID: WP_112151483.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EJP79_RS23750269345..271444+2100WP_119262374.1lipase family protein-
EJP79_RS23755271458..272198+741WP_165497368.1hypothetical protein-
EJP79_RS23760272269..273009+741WP_162906109.1hypothetical protein-
EJP79_RS23765273405..273821+417WP_166861180.1hypothetical protein-
EJP79_RS25035273929..274183-255WP_205963718.1hypothetical protein-
EJP79_RS25040274116..274361-246WP_205963719.1HipA N-terminal domain-containing proteinToxin
EJP79_RS23775274366..274662-297WP_121019978.1helix-turn-helix transcriptional regulatorAntitoxin
EJP79_RS23780274850..275560+711WP_013577982.1GntR family transcriptional regulator-
EJP79_RS23785275571..276770-1200WP_013577983.12-dehydro-3-deoxy-6-phosphogalactonate aldolase-
EJP79_RS23790277095..278495+1401WP_014416613.1PTS transporter subunit EIIC-
EJP79_RS23795278502..279374-873WP_112151483.1fumarylacetoacetate hydrolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaRAHN-2mgtB / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / hcp/tssD / hcp/tssD1..556163556163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-74)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-68)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9422.50 Da        Isoelectric Point: 4.9670

>T116916 WP_205963719.1 NZ_CP034839:c274361-274116 [Rahnella aquatilis]
MRRAQQRLAIWMNGIPVGYWDKQKGEDRLQYSPEWTEDPQGRPLSLSLPFTPGNQVHRGNVVRDYFDNLLPDQQDPAQAL
D

Download         Length: 246 bp

>T116916 NZ_CP034839:c274361-274116 [Rahnella aquatilis]
ATGCGTCGTGCGCAGCAGCGTTTAGCGATATGGATGAACGGTATTCCTGTGGGGTACTGGGATAAGCAAAAAGGCGAGGA
TCGTTTACAGTACTCGCCCGAATGGACAGAGGACCCACAAGGGCGACCTTTGTCGCTTTCCCTGCCGTTTACGCCGGGTA
ATCAGGTGCATCGCGGCAATGTGGTTCGCGATTATTTTGATAATTTATTACCTGATCAGCAAGATCCTGCGCAGGCATTG
GATTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11215.90 Da        Isoelectric Point: 9.5099

>AT116916 WP_121019978.1 NZ_CP034839:c274662-274366 [Rahnella aquatilis]
MNTVYPLKTLNQLRPLLVGFRKEKGLTQKDVSEKLGVTQQTYARLEANPATASLDRLFRVFNVLGIEMVFSSQSDPEKPS
MEEIKPDYLSTPARKEQW

Download         Length: 297 bp

>AT116916 NZ_CP034839:c274662-274366 [Rahnella aquatilis]
ATGAATACAGTCTATCCGTTAAAAACACTTAACCAGCTCCGTCCGTTACTGGTGGGGTTCCGTAAGGAAAAAGGTCTGAC
GCAAAAGGATGTGTCAGAAAAACTGGGCGTGACCCAGCAGACATATGCCCGACTGGAGGCAAACCCTGCTACTGCCAGCC
TTGACCGGCTGTTTCGGGTATTTAATGTGTTGGGCATTGAGATGGTGTTTTCCTCACAATCCGATCCTGAAAAACCCTCT
ATGGAGGAAATCAAGCCGGATTATTTAAGTACGCCCGCCAGAAAGGAACAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References