Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 364373..366192 Replicon plasmid pKM05
Accession NZ_CP034837
Organism Rahnella aquatilis strain KM05

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EJP80_RS24700 Protein ID WP_119262329.1
Coordinates 364843..366192 (-) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID H8P0A0
Locus tag EJP80_RS24695 Protein ID WP_013578106.1
Coordinates 364373..364846 (-) Length 158 a.a.

Genomic Context

EJP80_RS24670EJP80_RS24675EJP80_RS24680EJP80_RS24685EJP80_RS24690EJP80_RS24730EJP80_RS24735EJP80_RS24740EJP80_RS24695EJP80_RS24700EJP80_RS24705EJP80_RS24710EJP80_RS24715EJP80_RS24720EJP80_RS24725
Location: 360053..361552 (1500 bp)
Type: Others
Protein ID: WP_013578103.1
Location: 361612..362181 (570 bp)
Type: Others
Protein ID: WP_121019887.1
Location: 362221..362934 (714 bp)
Type: Others
Protein ID: WP_112151437.1
Location: 363022..363876 (855 bp)
Type: Others
Protein ID: WP_014416647.1
Location: 363992..364312 (321 bp)
Type: Others
Protein ID: WP_013578105.1
Location: 370087..370305 (219 bp)
Type: Others
Protein ID: WP_013578112.1
Location: 370470..370763 (294 bp)
Type: Others
Protein ID: Protein_368
Location: 370859..371077 (219 bp)
Type: Others
Protein ID: WP_014416654.1
Location: 364373..364846 (474 bp)
Type: Antitoxin
Protein ID: WP_013578106.1
Location: 364843..366192 (1350 bp)
Type: Toxin
Protein ID: WP_119262329.1
Location: 366388..366609 (222 bp)
Type: Others
Protein ID: WP_014416648.1
Location: 366777..367400 (624 bp)
Type: Others
Protein ID: WP_112151436.1
Location: 367397..367918 (522 bp)
Type: Others
Protein ID: WP_041673402.1
Location: 367896..369221 (1326 bp)
Type: Others
Protein ID: WP_014416651.1
Location: 369334..369684 (351 bp)
Type: Others
Protein ID: WP_112151587.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EJP80_RS24670360053..361552+1500WP_013578103.1UbiD family decarboxylase-
EJP80_RS24675361612..362181+570WP_121019887.1UbiX family flavin prenyltransferase-
EJP80_RS24680362221..362934+714WP_112151437.1DUF554 domain-containing protein-
EJP80_RS24685363022..363876+855WP_014416647.1LysR family transcriptional regulator-
EJP80_RS24690363992..364312+321WP_013578105.1multidrug efflux SMR transporter-
EJP80_RS24695364373..364846-474WP_013578106.1helix-turn-helix domain-containing proteinAntitoxin
EJP80_RS24700364843..366192-1350WP_119262329.1type II toxin-antitoxin system HipA family toxinToxin
EJP80_RS24705366388..366609-222WP_014416648.1DUF1471 domain-containing protein-
EJP80_RS24710366777..367400-624WP_112151436.1NAD(P)H-binding protein-
EJP80_RS24715367397..367918-522WP_041673402.1heme utilization cystosolic carrier protein HutX-
EJP80_RS24720367896..369221-1326WP_014416651.1heme anaerobic degradation radical SAM methyltransferase ChuW/HutW-
EJP80_RS24725369334..369684-351WP_112151587.1hypothetical protein-
EJP80_RS24730370087..370305+219WP_013578112.1YgdI/YgdR family lipoprotein-
EJP80_RS24735370470..370763+294Protein_368iron dicitrate ABC transporter ATP-binding protein-
EJP80_RS24740370859..371077+219WP_014416654.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-381)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-139)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51233.66 Da        Isoelectric Point: 4.6576

>T116913 WP_119262329.1 NZ_CP034837:c366192-364843 [Rahnella aquatilis]
MEFLTLQAFLNNTWVDIANITFPGSEQNNYRLTELNYHSDYAIDNLDRDDNHAASLNHPVSLFFDGDDERGWLKFLDDII
PSGSSRRYWANYLDLEGLTADQQNFILLKHGTLSPVGNLRIKESLPEYNPLAEKLFFTIEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRCSQEQQIWIDTYQNDTANRDIPYLVKYPRGARTEVDCNILRAEFYFYHELEAMGFDTIPTQNMR
LEEGLTYPSLWLPRFDISFEEEGLIRRFGMESVYSLLRKAPGVTLYHEETLRALIDKISHSHMVTEQGFDFDIPGFVTEW
VQRDLLNIIFGNSDNHGRNTSFLKDERSIRLAPIYDFAPMKADPEGIARTTKWKAPLEIGGEYDYPGIAQSLDDLVPAET
LLSALKNTSHQLSGLKERLEARGIPQQILNMPAISFSFIPEKLRRWGLL

Download         Length: 1350 bp

>T116913 NZ_CP034837:c366192-364843 [Rahnella aquatilis]
ATGGAATTTTTAACGTTACAAGCTTTCCTCAATAATACCTGGGTTGATATTGCTAACATCACTTTTCCCGGCAGTGAGCA
GAATAACTATCGTCTGACCGAACTGAATTATCATTCGGATTACGCTATTGATAACCTTGATCGTGACGATAACCATGCCG
CATCGTTGAATCACCCCGTCTCTTTGTTTTTTGATGGTGACGATGAGCGGGGTTGGCTGAAGTTTCTTGATGATATTATT
CCCAGCGGTTCAAGTCGCCGCTATTGGGCAAACTATCTCGATCTCGAAGGACTGACAGCCGATCAGCAAAATTTCATTTT
GCTCAAACATGGCACCTTGTCCCCTGTTGGCAATCTGCGCATAAAAGAATCATTACCGGAATATAATCCGCTGGCTGAAA
AACTTTTCTTCACTATAGAAGATGTTAAAAACCGGGCGGGTGACTTTCTGGACTACGCACAACAACGCGGTGCGGCTGCC
GGTGGCGCGACAGGCGCCGGGGGCGAAGCACCAAAGCTGTTGCTGCGTTGTAGTCAGGAACAGCAAATCTGGATTGATAC
CTACCAGAATGACACTGCCAACCGGGACATTCCCTATTTGGTCAAATATCCCCGTGGCGCAAGAACAGAGGTAGACTGCA
ATATTCTTCGGGCAGAATTCTATTTCTACCATGAGCTTGAAGCCATGGGGTTTGACACGATCCCGACGCAAAACATGCGG
CTGGAAGAAGGGCTGACTTATCCGTCACTCTGGCTTCCGCGTTTTGATATTTCTTTTGAAGAGGAAGGACTTATCAGACG
TTTCGGAATGGAATCAGTCTATTCACTCCTGCGCAAAGCGCCCGGTGTGACGCTGTATCATGAAGAAACCCTCCGTGCAC
TGATCGATAAGATTTCACACAGTCATATGGTGACAGAACAAGGTTTTGATTTTGATATCCCGGGGTTTGTGACTGAATGG
GTACAACGAGATCTGCTCAATATTATTTTTGGTAACAGCGATAATCATGGGCGTAACACCTCTTTCCTGAAAGATGAACG
CAGCATCCGGCTTGCACCAATCTACGATTTTGCGCCGATGAAAGCCGATCCGGAAGGTATTGCCAGAACGACGAAATGGA
AGGCTCCGCTGGAAATCGGCGGTGAATACGATTATCCCGGCATTGCACAATCACTCGATGATCTTGTCCCGGCAGAAACA
TTACTTTCGGCACTTAAAAACACGTCACATCAACTGTCGGGACTGAAAGAGCGGCTGGAAGCCCGTGGCATACCGCAGCA
AATTTTGAACATGCCCGCGATAAGTTTCAGTTTTATTCCTGAAAAGTTACGCCGCTGGGGGTTGTTATGA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17587.18 Da        Isoelectric Point: 10.9653

>AT116913 WP_013578106.1 NZ_CP034837:c364846-364373 [Rahnella aquatilis]
MKEPEIAANSARNTIDKIRAKQNEANHVRRDAGQMLAQEETSSTGKKQAQRRVSNLTKPVSTNDRNQARLDIMRALLLGE
ITQGQALKALRITVLGLKQDAFGKLVTVSRKTLSEVENDKGNYTPDIINKLFRPFGLKVGLVPVSQQIFRTLFERSE

Download         Length: 474 bp

>AT116913 NZ_CP034837:c364846-364373 [Rahnella aquatilis]
ATGAAAGAACCAGAGATTGCCGCAAACTCTGCGAGAAATACCATTGATAAAATACGGGCTAAACAAAATGAGGCGAATCA
TGTGCGGCGTGACGCCGGACAAATGCTGGCTCAGGAAGAAACATCTTCCACGGGAAAAAAACAAGCCCAGCGAAGAGTGT
CGAACCTGACGAAACCCGTCAGCACCAATGACCGAAATCAAGCCCGGCTCGACATCATGCGGGCGTTACTTTTGGGTGAA
ATCACGCAGGGACAAGCACTAAAAGCACTGAGGATTACGGTGCTGGGGTTAAAACAAGACGCCTTTGGGAAATTAGTGAC
AGTGTCACGTAAGACGCTATCAGAAGTGGAAAATGATAAGGGAAATTACACGCCTGACATCATCAACAAACTGTTTAGAC
CATTTGGCCTGAAAGTCGGGCTGGTGCCGGTTTCTCAGCAGATATTCAGGACTCTCTTTGAGCGCAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBH8P0A0

References