Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4168..4760 Replicon plasmid pTB602
Accession NZ_CP034833
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag EOS98_RS24370 Protein ID WP_000520549.1
Coordinates 4168..4416 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag EOS98_RS24375 Protein ID WP_000681613.1
Coordinates 4413..4760 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS24335 1045..1560 + 516 WP_001025395.1 J domain-containing protein -
EOS98_RS24340 1665..2207 + 543 WP_001083906.1 hypothetical protein -
EOS98_RS24345 2204..2455 + 252 WP_001230707.1 hypothetical protein -
EOS98_RS24350 2442..2669 + 228 WP_000801440.1 hypothetical protein -
EOS98_RS24360 3123..3422 + 300 WP_000650309.1 hypothetical protein -
EOS98_RS24365 3513..3863 + 351 WP_000854259.1 hypothetical protein -
EOS98_RS24370 4168..4416 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
EOS98_RS24375 4413..4760 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EOS98_RS24385 5121..5624 + 504 WP_000781813.1 hypothetical protein -
EOS98_RS24390 5628..6857 + 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
EOS98_RS24395 6934..7227 + 294 WP_060598542.1 LuxR family transcriptional regulator -
EOS98_RS24400 7224..7439 + 216 WP_000760375.1 EexN family lipoprotein -
EOS98_RS24405 7795..8415 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
EOS98_RS24410 8483..8755 + 273 WP_001328551.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-1.1 - 1..33303 33303


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T116910 WP_000520549.1 NZ_CP034833:4168-4416 [Salmonella sp. SSDFZ69]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

>T116910 NZ_CP034833:4168-4416 [Salmonella sp. SSDFZ69]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT116910 WP_000681613.1 NZ_CP034833:4413-4760 [Salmonella sp. SSDFZ69]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp

>AT116910 NZ_CP034833:4413-4760 [Salmonella sp. SSDFZ69]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References