Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4031235..4031751 Replicon chromosome
Accession NZ_CP034831
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag EOS98_RS19985 Protein ID WP_000220577.1
Coordinates 4031235..4031519 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag EOS98_RS19990 Protein ID WP_000212724.1
Coordinates 4031509..4031751 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS19970 4026447..4028099 + 1653 WP_126524329.1 alpha,alpha-phosphotrehalase -
EOS98_RS19975 4028508..4030646 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
EOS98_RS19980 4030767..4031231 + 465 WP_031605772.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EOS98_RS19985 4031235..4031519 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EOS98_RS19990 4031509..4031751 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EOS98_RS19995 4031829..4033742 - 1914 WP_140902122.1 BglG family transcription antiterminator -
EOS98_RS20000 4033759..4034499 - 741 WP_126524331.1 KDGP aldolase family protein -
EOS98_RS20005 4034496..4035614 - 1119 WP_126524332.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
EOS98_RS20010 4035598..4036731 - 1134 WP_126524333.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T116905 WP_000220577.1 NZ_CP034831:c4031519-4031235 [Salmonella sp. SSDFZ69]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T116905 NZ_CP034831:c4031519-4031235 [Salmonella sp. SSDFZ69]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT116905 WP_000212724.1 NZ_CP034831:c4031751-4031509 [Salmonella sp. SSDFZ69]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT116905 NZ_CP034831:c4031751-4031509 [Salmonella sp. SSDFZ69]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References