Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3344965..3345585 Replicon chromosome
Accession NZ_CP034831
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EOS98_RS16735 Protein ID WP_001280991.1
Coordinates 3345367..3345585 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag EOS98_RS16730 Protein ID WP_000344807.1
Coordinates 3344965..3345339 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS16720 3340104..3341297 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EOS98_RS16725 3341320..3344469 + 3150 WP_126524222.1 efflux RND transporter permease AcrB -
EOS98_RS16730 3344965..3345339 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
EOS98_RS16735 3345367..3345585 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
EOS98_RS16740 3345764..3346315 + 552 WP_001278793.1 maltose O-acetyltransferase -
EOS98_RS16745 3346433..3346903 + 471 WP_126524223.1 hypothetical protein -
EOS98_RS16750 3346959..3347099 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
EOS98_RS16755 3347101..3347364 - 264 WP_000801416.1 type B 50S ribosomal protein L31 -
EOS98_RS16760 3347589..3349139 + 1551 WP_126524224.1 EAL domain-containing protein -
EOS98_RS16770 3349370..3349759 + 390 WP_126524225.1 MGMT family protein -
EOS98_RS16775 3349792..3350361 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T116901 WP_001280991.1 NZ_CP034831:3345367-3345585 [Salmonella sp. SSDFZ69]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T116901 NZ_CP034831:3345367-3345585 [Salmonella sp. SSDFZ69]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAACTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT116901 WP_000344807.1 NZ_CP034831:3344965-3345339 [Salmonella sp. SSDFZ69]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT116901 NZ_CP034831:3344965-3345339 [Salmonella sp. SSDFZ69]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References