Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1851352..1851942 Replicon chromosome
Accession NZ_CP034831
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name pemK Uniprot ID A0A3S5G4X7
Locus tag EOS98_RS08980 Protein ID WP_039591092.1
Coordinates 1851610..1851942 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3V3TWU4
Locus tag EOS98_RS08975 Protein ID WP_039520052.1
Coordinates 1851352..1851609 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS24695 1848680..1849942 - 1263 WP_206612204.1 hypothetical protein -
EOS98_RS08960 1850328..1850801 + 474 WP_126523999.1 hypothetical protein -
EOS98_RS08965 1850798..1851004 + 207 WP_126524000.1 helix-turn-helix domain-containing protein -
EOS98_RS08975 1851352..1851609 + 258 WP_039520052.1 antitoxin Antitoxin
EOS98_RS08980 1851610..1851942 + 333 WP_039591092.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EOS98_RS08990 1852775..1853659 + 885 WP_126524002.1 integrase domain-containing protein -
EOS98_RS08995 1854689..1855951 - 1263 WP_126524003.1 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1841588..1851942 10354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11765.62 Da        Isoelectric Point: 10.5834

>T116892 WP_039591092.1 NZ_CP034831:1851610-1851942 [Salmonella sp. SSDFZ69]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARAAGFTVSLEGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T116892 NZ_CP034831:1851610-1851942 [Salmonella sp. SSDFZ69]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGTCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCCGTTGTTGTTCCCGTCACCAGCGGTGGAAACTTCGCCCGCG
CAGCCGGTTTTACCGTCTCACTGGAGGGGGCGGGAACAAAAACAACGGGCGTGATCCGCTGCGACCAGCCCAGAACTATT
GATATGGGCGCCCGAAATGGTAAGCGACTGGAGCGCATACCCGACGCTGTCGTGAATGAAGTGCTGGCCCGACTGGAAGC
CATTCTGAGCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9370.85 Da        Isoelectric Point: 4.4488

>AT116892 WP_039520052.1 NZ_CP034831:1851352-1851609 [Salmonella sp. SSDFZ69]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT116892 NZ_CP034831:1851352-1851609 [Salmonella sp. SSDFZ69]
ATGTATACAACTCGCCTGAAAAAGGTCGGCGGATCCGTCATGCTGGCGGTTCCTCCCGCCGTGTTGAAAACGCTGGCGCT
GTCGACAGATAGCGAAGTGGGTATGACCATTGATAATGGCTGCCTGATTATTGAACCCCAGAAACGGCCCCGCTATTCGC
TTGAGGAGCTGCTGGCGCAGTGCGATCCGCACGCCGAAATGAGTGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5G4X7

Antitoxin

Source ID Structure
AlphaFold DB A0A3V3TWU4

References