Detailed information of TA system TA116891

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1008264..1009078
• Replicon: chromosome
• Accession: NZ_CP034831
• Organism: Salmonella sp. SSDFZ69

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: EOS98_RS04970
• Protein ID: WP_126523877.1
• Coordinates: 1008264..1008791 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: EOS98_RS04975
• Protein ID: WP_000855694.1
• Coordinates: 1008788..1009078 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS98_RS04950	1003564..1006131	-	2568	WP_001005802.1	DNA mismatch repair protein MutS	-
EOS98_RS04955	1006290..1006811	+	522	WP_061383865.1	hypothetical protein	-
EOS98_RS04960	1006983..1007639	-	657	WP_058821376.1	protein-serine/threonine phosphatase	-
EOS98_RS04965	1007968..1008191	+	224	Protein_941	IS5/IS1182 family transposase	-
EOS98_RS04970	1008264..1008791	-	528	WP_126523877.1	GNAT family N-acetyltransferase	Toxin
EOS98_RS04975	1008788..1009078	-	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
EOS98_RS04980	1009348..1009533	-	186	Protein_944	IS3 family transposase	-
EOS98_RS04985	1009788..1010114	+	327	WP_000393302.1	hypothetical protein	-
EOS98_RS04990	1010387..1010734	-	348	WP_001669174.1	DUF1493 family protein	-
EOS98_RS04995	1010719..1011168	-	450	WP_023261375.1	hypothetical protein	-
EOS98_RS05000	1011599..1012042	-	444	WP_126523878.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
EOS98_RS05005	1012499..1013149	+	651	WP_001674874.1	type III secretion system transcriptional activator InvF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	invH / invF / invG / invE / invA / invB	1006983..1018462	11479
	-	flank	IS/Tn	-	-	1008051..1008191	140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19097.96 Da
• Isoelectric Point: 9.6420

>T116891 WP_126523877.1 NZ_CP034831:c1008791-1008264 [Salmonella sp. SSDFZ69]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHVRQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T116891 NZ_CP034831:c1008791-1008264 [Salmonella sp. SSDFZ69]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGTACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCTCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT116891 WP_000855694.1 NZ_CP034831:c1009078-1008788 [Salmonella sp. SSDFZ69]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT116891 NZ_CP034831:c1009078-1008788 [Salmonella sp. SSDFZ69]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7