Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843576..844236 Replicon chromosome
Accession NZ_CP034831
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag EOS98_RS04180 Protein ID WP_000244756.1
Coordinates 843823..844236 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag EOS98_RS04175 Protein ID WP_000351186.1
Coordinates 843576..843842 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS04150 839505..840938 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
EOS98_RS04155 841096..841407 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
EOS98_RS04160 841571..842230 + 660 WP_000250289.1 hemolysin III family protein -
EOS98_RS04170 842346..843326 - 981 WP_023254245.1 tRNA-modifying protein YgfZ -
EOS98_RS04175 843576..843842 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
EOS98_RS04180 843823..844236 + 414 WP_000244756.1 protein YgfX Toxin
EOS98_RS04185 844289..844810 - 522 WP_001055885.1 flavodoxin FldB -
EOS98_RS04190 844923..845819 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
EOS98_RS04195 845843..846556 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EOS98_RS04200 846562..848295 + 1734 WP_064012850.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T116890 WP_000244756.1 NZ_CP034831:843823-844236 [Salmonella sp. SSDFZ69]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T116890 NZ_CP034831:843823-844236 [Salmonella sp. SSDFZ69]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGCCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT116890 WP_000351186.1 NZ_CP034831:843576-843842 [Salmonella sp. SSDFZ69]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT116890 NZ_CP034831:843576-843842 [Salmonella sp. SSDFZ69]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References