Detailed information of TA system TA116889

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 323900..324486
• Replicon: chromosome
• Accession: NZ_CP034831
• Organism: Salmonella sp. SSDFZ69

Toxin (Protein)

• Gene name: doc
• Uniprot ID: A0A0R9MYB2
• Locus tag: EOS98_RS01515
• Protein ID: WP_000174966.1
• Coordinates: 324118..324486 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A0R9PI96
• Locus tag: EOS98_RS01510
• Protein ID: WP_001535398.1
• Coordinates: 323900..324121 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS98_RS01485	318918..320027	+	1110	WP_126523776.1	high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK	-
EOS98_RS01490	320089..321015	+	927	WP_126523777.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
EOS98_RS01495	321012..322289	+	1278	WP_000803764.1	branched chain amino acid ABC transporter permease LivM	-
EOS98_RS01500	322286..323053	+	768	WP_000082083.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
EOS98_RS01505	323055..323768	+	714	WP_000416114.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
EOS98_RS01510	323900..324121	+	222	WP_001535398.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EOS98_RS01515	324118..324486	+	369	WP_000174966.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
EOS98_RS01520	324745..326061	+	1317	WP_000624749.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
EOS98_RS01525	326166..327053	+	888	WP_000094074.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
EOS98_RS01530	327050..327895	+	846	WP_000572203.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
EOS98_RS01535	327898..328968	+	1071	WP_001646570.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	321012..329705	8693

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (1-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-49)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13629.91 Da
• Isoelectric Point: 6.4657

>T116889 WP_000174966.1 NZ_CP034831:324118-324486 [Salmonella sp. SSDFZ69]
MTLQLISAEEIIQFHDRLLRVTPGVTGMPDPGRAEALMYRVLNQIEYEGVTDVWLLAAMHLLTISRGYIFNDGNKRTALF
ITLLFLKRNGISLAANPDFVDMTVDAAAGRLTLEQIAVRLRA

Nucleotide

• Length: 369 bp

>T116889 NZ_CP034831:324118-324486 [Salmonella sp. SSDFZ69]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8165.23 Da
• Isoelectric Point: 6.4643

>AT116889 WP_001535398.1 NZ_CP034831:323900-324121 [Salmonella sp. SSDFZ69]
MRTVNYSEARQNLAEVLESAVTAGPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGNELRKLADK

Nucleotide

• Length: 222 bp

>AT116889 NZ_CP034831:323900-324121 [Salmonella sp. SSDFZ69]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0R9MYB2

Antitoxin

• AlphaFold DB: A0A0R9PI96