Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 213434..214194 Replicon chromosome
Accession NZ_CP034831
Organism Salmonella sp. SSDFZ69

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag EOS98_RS01025 Protein ID WP_000533909.1
Coordinates 213709..214194 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag EOS98_RS01020 Protein ID WP_000965889.1
Coordinates 213434..213721 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS98_RS01000 208780..210108 - 1329 WP_000200570.1 MFS transporter -
EOS98_RS01005 210296..211456 - 1161 WP_000107288.1 mandelate racemase/muconate lactonizing enzyme family protein -
EOS98_RS01010 211562..212461 + 900 WP_000462482.1 LysR family transcriptional regulator -
EOS98_RS01015 212598..213251 - 654 WP_126523757.1 LysE family translocator -
EOS98_RS01020 213434..213721 + 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
EOS98_RS01025 213709..214194 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
EOS98_RS01030 214565..215104 - 540 WP_126523758.1 copper-binding periplasmic metallochaperone CueP -
EOS98_RS01035 215277..215489 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
EOS98_RS01040 215777..216067 - 291 WP_000455790.1 HTH-type transcriptional regulator -
EOS98_RS01045 216506..217216 + 711 WP_000190524.1 DUF3053 domain-containing protein -
EOS98_RS01050 217266..218240 - 975 WP_000804684.1 glyoxylate/hydroxypyruvate reductase GhrB -
EOS98_RS01055 218459..219121 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T116888 WP_000533909.1 NZ_CP034831:213709-214194 [Salmonella sp. SSDFZ69]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T116888 NZ_CP034831:213709-214194 [Salmonella sp. SSDFZ69]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT116888 WP_000965889.1 NZ_CP034831:213434-213721 [Salmonella sp. SSDFZ69]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT116888 NZ_CP034831:213434-213721 [Salmonella sp. SSDFZ69]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References