Detailed information of TA system TA116885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 4362686..4363208
• Replicon: chromosome
• Accession: NZ_CP034819
• Organism: Salmonella sp. SSDFZ54

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A8E5IJC7
• Locus tag: EOS97_RS21635
• Protein ID: WP_000221347.1
• Coordinates: 4362924..4363208 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: EOS97_RS21630
• Protein ID: WP_000885424.1
• Coordinates: 4362686..4362934 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS97_RS21595	4358575..4358763	+	189	WP_001276026.1	DUF29 family protein	-
EOS97_RS21605	4359122..4359912	+	791	Protein_4066	helix-turn-helix domain containing protein	-
EOS97_RS21610	4359914..4360666	-	753	Protein_4067	hypothetical protein	-
EOS97_RS21620	4361528..4361917	+	390	WP_001044696.1	hypothetical protein	-
EOS97_RS21630	4362686..4362934	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EOS97_RS21635	4362924..4363208	+	285	WP_000221347.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EOS97_RS21640	4363379..4363768	+	390	WP_000194089.1	RidA family protein	-
EOS97_RS21645	4363826..4364899	-	1074	WP_000954689.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
EOS97_RS21650	4365092..4365580	-	489	WP_001293634.1	MarR family winged helix-turn-helix transcriptional regulator	-
EOS97_RS21655	4365625..4367133	+	1509	WP_000199412.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4354481..4369989	15508

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11074.86 Da
• Isoelectric Point: 10.7615

>T116885 WP_000221347.1 NZ_CP034819:4362924-4363208 [Salmonella sp. SSDFZ54]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKNQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T116885 NZ_CP034819:4362924-4363208 [Salmonella sp. SSDFZ54]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGAATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT116885 WP_000885424.1 NZ_CP034819:4362686-4362934 [Salmonella sp. SSDFZ54]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT116885 NZ_CP034819:4362686-4362934 [Salmonella sp. SSDFZ54]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A5I0WPN5