Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3247058..3247678 Replicon chromosome
Accession NZ_CP034819
Organism Salmonella sp. SSDFZ54

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag EOS97_RS16025 Protein ID WP_001280991.1
Coordinates 3247058..3247276 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag EOS97_RS16030 Protein ID WP_000344807.1
Coordinates 3247304..3247678 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS97_RS15985 3242282..3242851 + 570 WP_000779802.1 YbaY family lipoprotein -
EOS97_RS15990 3242884..3243273 - 390 WP_000961285.1 MGMT family protein -
EOS97_RS16000 3243504..3245054 - 1551 WP_000213145.1 EAL domain-containing protein -
EOS97_RS16005 3245279..3245539 + 261 WP_000801411.1 type B 50S ribosomal protein L31 -
EOS97_RS16010 3245545..3245685 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
EOS97_RS16015 3245741..3246211 - 471 WP_000136183.1 membrane protein -
EOS97_RS16020 3246328..3246879 - 552 WP_001278793.1 maltose O-acetyltransferase -
EOS97_RS16025 3247058..3247276 - 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
EOS97_RS16030 3247304..3247678 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
EOS97_RS16035 3248174..3251323 - 3150 WP_001132508.1 multidrug efflux RND transporter permease subunit -
EOS97_RS16040 3251346..3252539 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T116875 WP_001280991.1 NZ_CP034819:c3247276-3247058 [Salmonella sp. SSDFZ54]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T116875 NZ_CP034819:c3247276-3247058 [Salmonella sp. SSDFZ54]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT116875 WP_000344807.1 NZ_CP034819:c3247678-3247304 [Salmonella sp. SSDFZ54]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT116875 NZ_CP034819:c3247678-3247304 [Salmonella sp. SSDFZ54]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References