116871

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2568345..2568861 Replicon chromosome
Accession NZ_CP034819
Organism Salmonella sp. SSDFZ54

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag EOS97_RS12790 Protein ID WP_000220577.1
Coordinates 2568577..2568861 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag EOS97_RS12785 Protein ID WP_000212724.1
Coordinates 2568345..2568587 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS97_RS12765 2563365..2564498 + 1134 WP_000459941.1 amidohydrolase/deacetylase family metallohydrolase -
EOS97_RS12770 2564482..2565600 + 1119 WP_001139181.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
EOS97_RS12775 2565597..2566337 + 741 WP_000779267.1 KDGP aldolase family protein -
EOS97_RS12780 2566354..2568267 + 1914 WP_001212145.1 BglG family transcription antiterminator -
EOS97_RS12785 2568345..2568587 + 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EOS97_RS12790 2568577..2568861 + 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EOS97_RS12795 2568865..2569329 - 465 WP_001268863.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
EOS97_RS12800 2569450..2571588 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
EOS97_RS12805 2571997..2573649 - 1653 WP_000155037.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T116871 WP_000220577.1 NZ_CP034819:2568577-2568861 [Salmonella sp. SSDFZ54]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T116871 NZ_CP034819:2568577-2568861 [Salmonella sp. SSDFZ54]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT116871 WP_000212724.1 NZ_CP034819:2568345-2568587 [Salmonella sp. SSDFZ54]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT116871 NZ_CP034819:2568345-2568587 [Salmonella sp. SSDFZ54]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References