116868

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1724898..1725658 Replicon chromosome
Accession NZ_CP034819
Organism Salmonella sp. SSDFZ54

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag EOS97_RS08650 Protein ID WP_000533909.1
Coordinates 1724898..1725383 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID Q8Z2B2
Locus tag EOS97_RS08655 Protein ID WP_000965889.1
Coordinates 1725371..1725658 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS97_RS08620 1719963..1720625 + 663 WP_000747548.1 OmpA family lipoprotein -
EOS97_RS08625 1720851..1721825 + 975 WP_000804670.1 glyoxylate/hydroxypyruvate reductase GhrB -
EOS97_RS08630 1721875..1722585 - 711 WP_127836138.1 DUF3053 domain-containing protein -
EOS97_RS08635 1723024..1723314 + 291 WP_000455790.1 HTH-type transcriptional regulator -
EOS97_RS08640 1723602..1723814 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
EOS97_RS08645 1723987..1724526 + 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
EOS97_RS08650 1724898..1725383 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
EOS97_RS08655 1725371..1725658 - 288 WP_000965889.1 DUF1778 domain-containing protein Antitoxin
EOS97_RS08660 1725781..1726361 - 581 Protein_1625 HNH endonuclease -
EOS97_RS08670 1727835..1728605 + 771 WP_000456879.1 DUF3800 domain-containing protein -
EOS97_RS08675 1728831..1729022 - 192 WP_001541099.1 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T116868 WP_000533909.1 NZ_CP034819:c1725383-1724898 [Salmonella sp. SSDFZ54]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T116868 NZ_CP034819:c1725383-1724898 [Salmonella sp. SSDFZ54]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 4.6811

>AT116868 WP_000965889.1 NZ_CP034819:c1725658-1725371 [Salmonella sp. SSDFZ54]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT116868 NZ_CP034819:c1725658-1725371 [Salmonella sp. SSDFZ54]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATTAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
AlphaFold DB A0A752RW74

References