Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 947111..947771 Replicon chromosome
Accession NZ_CP034819
Organism Salmonella sp. SSDFZ54

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag EOS97_RS04520 Protein ID WP_000244756.1
Coordinates 947111..947524 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag EOS97_RS04525 Protein ID WP_000351186.1
Coordinates 947505..947771 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOS97_RS04500 943052..944785 - 1734 WP_000813386.1 single-stranded-DNA-specific exonuclease RecJ -
EOS97_RS04505 944791..945504 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EOS97_RS04510 945528..946424 - 897 WP_000434303.1 site-specific tyrosine recombinase XerD -
EOS97_RS04515 946537..947058 + 522 WP_001055885.1 flavodoxin FldB -
EOS97_RS04520 947111..947524 - 414 WP_000244756.1 protein YgfX Toxin
EOS97_RS04525 947505..947771 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
EOS97_RS04530 948021..949001 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
EOS97_RS04540 949117..949776 - 660 WP_000250289.1 hemolysin III family protein -
EOS97_RS04545 949940..950251 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
EOS97_RS04550 950409..951842 + 1434 WP_023165909.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T116867 WP_000244756.1 NZ_CP034819:c947524-947111 [Salmonella sp. SSDFZ54]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T116867 NZ_CP034819:c947524-947111 [Salmonella sp. SSDFZ54]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
ACATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT116867 WP_000351186.1 NZ_CP034819:c947771-947505 [Salmonella sp. SSDFZ54]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT116867 NZ_CP034819:c947771-947505 [Salmonella sp. SSDFZ54]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References