Detailed information of TA system TA116866

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 780210..781024
• Replicon: chromosome
• Accession: NZ_CP034819
• Organism: Salmonella sp. SSDFZ54

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E5IG67
• Locus tag: EOS97_RS03720
• Protein ID: WP_000971651.1
• Coordinates: 780497..781024 (+)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: M7S6I2
• Locus tag: EOS97_RS03715
• Protein ID: WP_000855694.1
• Coordinates: 780210..780500 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EOS97_RS03690	776254..776904	-	651	WP_001728903.1	type III secretion system transcriptional activator InvF	-
EOS97_RS03695	777361..777804	+	444	WP_000715095.1	SPI-1 type III secretion system invasion lipoprotein InvH	-
EOS97_RS03700	778236..778685	+	450	WP_000381609.1	hypothetical protein	-
EOS97_RS03705	778670..779017	+	348	WP_001555786.1	DUF1493 family protein	-
EOS97_RS03710	779290..779616	-	327	WP_000393295.1	hypothetical protein	-
EOS97_RS03715	780210..780500	+	291	WP_000855694.1	DUF1778 domain-containing protein	Antitoxin
EOS97_RS03720	780497..781024	+	528	WP_000971651.1	GNAT family N-acetyltransferase	Toxin
EOS97_RS03725	781097..781515	-	419	Protein_697	transposase	-
EOS97_RS03730	781748..782404	+	657	WP_000420450.1	protein-serine/threonine phosphatase	-
EOS97_RS03735	782649..783143	-	495	WP_000424946.1	hypothetical protein	-
EOS97_RS03740	783170..783838	-	669	WP_000445914.1	hypothetical protein	-
EOS97_RS03745	783995..784213	-	219	Protein_701	hypothetical protein	-
EOS97_RS03750	784424..784822	-	399	Protein_702	cytoplasmic protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	781097..781273	176

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 18970.77 Da
• Isoelectric Point: 9.3905

>T116866 WP_000971651.1 NZ_CP034819:780497-781024 [Salmonella sp. SSDFZ54]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGGYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Nucleotide

• Length: 528 bp

>T116866 NZ_CP034819:780497-781024 [Salmonella sp. SSDFZ54]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGAAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGGGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTACTG
TCGTTTAAAACGCTTTATGCGGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.50 Da
• Isoelectric Point: 6.3133

>AT116866 WP_000855694.1 NZ_CP034819:780210-780500 [Salmonella sp. SSDFZ54]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Nucleotide

• Length: 291 bp

>AT116866 NZ_CP034819:780210-780500 [Salmonella sp. SSDFZ54]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A3V8SJE7