Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 18040..18601 Replicon plasmid unnamed5
Accession NZ_CP034815
Organism Paracoccus sp. Arc7-R13

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag EOJ32_RS19175 Protein ID WP_081994710.1
Coordinates 18326..18601 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag EOJ32_RS19170 Protein ID WP_081994709.1
Coordinates 18040..18333 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOJ32_RS19150 14114..15000 + 887 Protein_15 DUF1738 domain-containing protein -
EOJ32_RS20210 15167..15331 + 165 WP_164871516.1 hypothetical protein -
EOJ32_RS19155 15716..16123 - 408 WP_127899926.1 hypothetical protein -
EOJ32_RS19160 16120..16413 - 294 WP_127899927.1 hypothetical protein -
EOJ32_RS19170 18040..18333 + 294 WP_081994709.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EOJ32_RS19175 18326..18601 + 276 WP_081994710.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
EOJ32_RS19180 18737..19078 + 342 WP_127899928.1 hypothetical protein -
EOJ32_RS19185 19442..19921 + 480 WP_127899929.1 cytochrome c -
EOJ32_RS19190 19818..20459 + 642 WP_127899930.1 DUF411 domain-containing protein -
EOJ32_RS19195 20486..21019 + 534 WP_052714941.1 L,D-transpeptidase family protein -
EOJ32_RS19200 21134..21541 + 408 WP_127899931.1 hypothetical protein -
EOJ32_RS19205 21729..22094 - 366 Protein_27 transposase -
EOJ32_RS19210 22231..23511 + 1281 WP_045983797.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..65353 65353
- inside IScluster/Tn - - 16588..24333 7745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-54)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10229.89 Da        Isoelectric Point: 5.0052

>T116864 WP_081994710.1 NZ_CP034815:18326-18601 [Paracoccus sp. Arc7-R13]
VPELEWNTFAVADLMAIVDYISDDNPDAALALMEEIQGKVAQLPMHPKRCRSGRVQGTRELVVRPNYIVIYAETPSVVTI
LRVLHAAQMWP

Download         Length: 276 bp

>T116864 NZ_CP034815:18326-18601 [Paracoccus sp. Arc7-R13]
GTGCCTGAACTCGAATGGAACACCTTCGCGGTCGCCGACCTCATGGCAATTGTCGACTATATCTCGGATGACAATCCTGA
TGCTGCTCTTGCTCTGATGGAGGAAATTCAGGGGAAGGTTGCGCAACTTCCAATGCATCCCAAGCGGTGCCGGTCAGGAC
GCGTTCAGGGAACACGTGAGTTGGTCGTTCGCCCGAACTACATTGTCATCTATGCTGAGACGCCGTCTGTCGTGACGATC
CTACGCGTGCTTCATGCCGCGCAGATGTGGCCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10276.67 Da        Isoelectric Point: 6.4753

>AT116864 WP_081994709.1 NZ_CP034815:18040-18333 [Paracoccus sp. Arc7-R13]
MPTHTSMLHVRVDDHLKAEASSALAGVGLTLSDAVRILLTRVAAEGGLPAGLTANPESYDSWFRAKVQEALTDTRPGVPH
DQVMCDARALIDGKRGA

Download         Length: 294 bp

>AT116864 NZ_CP034815:18040-18333 [Paracoccus sp. Arc7-R13]
ATGCCCACCCATACCTCAATGCTGCATGTCCGAGTGGACGATCATCTCAAGGCAGAGGCCAGTAGCGCACTGGCAGGTGT
AGGCCTGACCCTATCAGACGCAGTCCGTATCCTGCTGACCCGTGTGGCGGCTGAAGGGGGTCTGCCGGCCGGTCTGACTG
CAAATCCTGAAAGCTATGATAGCTGGTTTCGTGCGAAGGTGCAGGAAGCGCTGACAGACACCCGGCCTGGCGTTCCACAT
GACCAGGTCATGTGTGACGCCCGGGCATTGATCGACGGCAAACGGGGTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References