Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 152162..152640 Replicon chromosome
Accession NZ_CP034808
Organism Escherichia coli strain 08-3914

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AYP36_RS00805 Protein ID WP_001303876.1
Coordinates 152353..152640 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AYP36_RS00800 Protein ID WP_000536233.1
Coordinates 152162..152353 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP36_RS00765 147566..148336 - 771 WP_000450992.1 DUF1627 domain-containing protein -
AYP36_RS00770 148358..149104 - 747 WP_000788745.1 ATP-binding protein -
AYP36_RS00775 149111..150202 - 1092 WP_001205823.1 hypothetical protein -
AYP36_RS00780 150281..150736 + 456 WP_000273724.1 hypothetical protein -
AYP36_RS00785 150943..151368 - 426 WP_000693855.1 Rha family transcriptional regulator -
AYP36_RS00790 151352..151624 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AYP36_RS00795 151733..152134 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AYP36_RS00800 152162..152353 + 192 WP_000536233.1 hypothetical protein Antitoxin
AYP36_RS00805 152353..152640 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYP36_RS00815 152918..153073 + 156 WP_000379575.1 DUF1391 family protein -
AYP36_RS00820 153215..153604 + 390 WP_000394511.1 hypothetical protein -
AYP36_RS00825 153791..153976 - 186 WP_001133046.1 hypothetical protein -
AYP36_RS00835 154538..154726 + 189 WP_000413705.1 cell division inhibition protein DicB -
AYP36_RS00840 154723..154914 + 192 WP_001098307.1 DUF1482 family protein -
AYP36_RS00845 155008..157479 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116830 WP_001303876.1 NZ_CP034808:152353-152640 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116830 NZ_CP034808:152353-152640 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116830 WP_000536233.1 NZ_CP034808:152162-152353 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116830 NZ_CP034808:152162-152353 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References