Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2651308..2651786 Replicon chromosome
Accession NZ_CP034806
Organism Escherichia coli strain 2010C-3347

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A1D75_RS13970 Protein ID WP_001303876.1
Coordinates 2651499..2651786 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A1D75_RS13965 Protein ID WP_000536233.1
Coordinates 2651308..2651499 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1D75_RS13930 2646712..2647482 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A1D75_RS13935 2647504..2648250 - 747 WP_000788751.1 ATP-binding protein -
A1D75_RS13940 2648257..2649348 - 1092 WP_001205823.1 hypothetical protein -
A1D75_RS13945 2649427..2649882 + 456 WP_000273724.1 hypothetical protein -
A1D75_RS13950 2650089..2650514 - 426 WP_000693855.1 Rha family transcriptional regulator -
A1D75_RS13955 2650498..2650770 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A1D75_RS13960 2650879..2651280 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A1D75_RS13965 2651308..2651499 + 192 WP_000536233.1 hypothetical protein Antitoxin
A1D75_RS13970 2651499..2651786 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1D75_RS13980 2652064..2652219 + 156 WP_000379575.1 DUF1391 family protein -
A1D75_RS13985 2652361..2652750 + 390 WP_000394511.1 hypothetical protein -
A1D75_RS13990 2652937..2653122 - 186 WP_001133046.1 hypothetical protein -
A1D75_RS14000 2653696..2653884 + 189 WP_000413705.1 cell division inhibition protein DicB -
A1D75_RS14005 2653881..2654072 + 192 WP_001098307.1 DUF1482 family protein -
A1D75_RS14010 2654166..2656637 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116813 WP_001303876.1 NZ_CP034806:2651499-2651786 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116813 NZ_CP034806:2651499-2651786 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116813 WP_000536233.1 NZ_CP034806:2651308-2651499 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116813 NZ_CP034806:2651308-2651499 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References