Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1115938..1116416 Replicon chromosome
Accession NZ_CP034803
Organism Escherichia coli strain 2009C-3554

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A0I22_RS06560 Protein ID WP_001303876.1
Coordinates 1116129..1116416 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A0I22_RS06555 Protein ID WP_000536233.1
Coordinates 1115938..1116129 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0I22_RS06520 1111342..1112112 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A0I22_RS06525 1112134..1112880 - 747 WP_000788751.1 ATP-binding protein -
A0I22_RS06530 1112887..1113978 - 1092 WP_001205823.1 hypothetical protein -
A0I22_RS06535 1114057..1114512 + 456 WP_000273724.1 hypothetical protein -
A0I22_RS06540 1114719..1115144 - 426 WP_000693855.1 Rha family transcriptional regulator -
A0I22_RS06545 1115128..1115400 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A0I22_RS06550 1115509..1115910 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A0I22_RS06555 1115938..1116129 + 192 WP_000536233.1 hypothetical protein Antitoxin
A0I22_RS06560 1116129..1116416 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A0I22_RS06570 1116694..1116849 + 156 WP_000379575.1 DUF1391 family protein -
A0I22_RS06575 1116991..1117380 + 390 WP_000394511.1 hypothetical protein -
A0I22_RS06580 1117567..1117752 - 186 WP_001133046.1 hypothetical protein -
A0I22_RS06590 1118326..1118514 + 189 WP_000413705.1 cell division inhibition protein DicB -
A0I22_RS06595 1118511..1118702 + 192 WP_001098307.1 DUF1482 family protein -
A0I22_RS06600 1118796..1121267 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116760 WP_001303876.1 NZ_CP034803:1116129-1116416 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116760 NZ_CP034803:1116129-1116416 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116760 WP_000536233.1 NZ_CP034803:1115938-1116129 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116760 NZ_CP034803:1115938-1116129 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References