Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 172452..172930 Replicon chromosome
Accession NZ_CP034799
Organism Escherichia coli strain 2009C-4687

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A0I37_RS00975 Protein ID WP_001303876.1
Coordinates 172643..172930 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A0I37_RS00970 Protein ID WP_000536233.1
Coordinates 172452..172643 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A0I37_RS00935 167856..168626 - 771 WP_000450992.1 DUF1627 domain-containing protein -
A0I37_RS00940 168648..169394 - 747 WP_000788745.1 ATP-binding protein -
A0I37_RS00945 169401..170492 - 1092 WP_001205823.1 hypothetical protein -
A0I37_RS00950 170571..171026 + 456 WP_000273724.1 hypothetical protein -
A0I37_RS00955 171233..171658 - 426 WP_000693855.1 Rha family transcriptional regulator -
A0I37_RS00960 171642..171914 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A0I37_RS00965 172023..172424 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A0I37_RS00970 172452..172643 + 192 WP_000536233.1 hypothetical protein Antitoxin
A0I37_RS00975 172643..172930 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A0I37_RS00985 173208..173363 + 156 WP_000379575.1 DUF1391 family protein -
A0I37_RS00990 173505..173894 + 390 WP_000394511.1 hypothetical protein -
A0I37_RS00995 174081..174266 - 186 WP_001133046.1 hypothetical protein -
A0I37_RS01005 174840..175028 + 189 WP_000413705.1 cell division inhibition protein DicB -
A0I37_RS01010 175025..175216 + 192 WP_001098307.1 DUF1482 family protein -
A0I37_RS01015 175310..177781 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116685 WP_001303876.1 NZ_CP034799:172643-172930 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116685 NZ_CP034799:172643-172930 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116685 WP_000536233.1 NZ_CP034799:172452-172643 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116685 NZ_CP034799:172452-172643 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References