Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5121106..5121901 Replicon chromosome
Accession NZ_CP034797
Organism Escherichia coli strain 08-3918

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag AYP37_RS26235 Protein ID WP_000854914.1
Coordinates 5121527..5121901 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag AYP37_RS26230 Protein ID WP_001280954.1
Coordinates 5121106..5121480 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP37_RS26195 5116461..5117366 + 906 WP_000203541.1 chemotaxis protein -
AYP37_RS26200 5117363..5118433 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
AYP37_RS26210 5118773..5119591 + 819 WP_127835397.1 DUF945 domain-containing protein -
AYP37_RS26215 5119682..5120167 + 486 WP_000214398.1 antirestriction protein -
AYP37_RS26220 5120183..5120659 + 477 WP_001186738.1 RadC family protein -
AYP37_RS26225 5120722..5120943 + 222 WP_001220314.1 DUF987 domain-containing protein -
AYP37_RS26230 5121106..5121480 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AYP37_RS26235 5121527..5121901 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
AYP37_RS26240 5121898..5122389 + 492 WP_000976853.1 hypothetical protein -
AYP37_RS26245 5122401..5122598 + 198 WP_000839282.1 DUF957 domain-containing protein -
AYP37_RS26250 5122683..5123525 + 843 WP_001280481.1 DUF4942 domain-containing protein -
AYP37_RS26260 5123996..5124934 + 939 WP_000351284.1 glyoxylate/hydroxypyruvate reductase GhrA -
AYP37_RS26265 5124989..5125726 + 738 WP_000283664.1 zinc-binding phosphatase -
AYP37_RS26270 5125750..5126304 + 555 WP_001001917.1 molecular chaperone YcdY -
AYP37_RS26275 5126406..5126897 + 492 WP_001301587.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T116679 WP_000854914.1 NZ_CP034797:5121527-5121901 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T116679 NZ_CP034797:5121527-5121901 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT116679 WP_001280954.1 NZ_CP034797:5121106-5121480 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT116679 NZ_CP034797:5121106-5121480 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References