Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4896900..4897378 Replicon chromosome
Accession NZ_CP034797
Organism Escherichia coli strain 08-3918

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag AYP37_RS24940 Protein ID WP_001303876.1
Coordinates 4896900..4897187 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag AYP37_RS24945 Protein ID WP_000536233.1
Coordinates 4897187..4897378 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP37_RS24900 4892049..4894520 - 2472 WP_000034474.1 exonuclease -
AYP37_RS24905 4894614..4894805 - 192 WP_001098307.1 DUF1482 family protein -
AYP37_RS24910 4894802..4894990 - 189 WP_000413705.1 cell division inhibition protein DicB -
AYP37_RS24920 4895564..4895749 + 186 WP_001133046.1 hypothetical protein -
AYP37_RS24925 4895936..4896325 - 390 WP_000394511.1 hypothetical protein -
AYP37_RS24930 4896467..4896622 - 156 WP_000379575.1 DUF1391 family protein -
AYP37_RS24940 4896900..4897187 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYP37_RS24945 4897187..4897378 - 192 WP_000536233.1 hypothetical protein Antitoxin
AYP37_RS24950 4897406..4897807 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
AYP37_RS24955 4897916..4898188 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
AYP37_RS24960 4898172..4898597 + 426 WP_000693855.1 Rha family transcriptional regulator -
AYP37_RS24965 4898804..4899259 - 456 WP_000273724.1 hypothetical protein -
AYP37_RS24970 4899338..4900429 + 1092 WP_001205823.1 hypothetical protein -
AYP37_RS24975 4900436..4901182 + 747 WP_000788745.1 ATP-binding protein -
AYP37_RS24980 4901204..4901974 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116676 WP_001303876.1 NZ_CP034797:c4897187-4896900 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116676 NZ_CP034797:c4897187-4896900 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116676 WP_000536233.1 NZ_CP034797:c4897378-4897187 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116676 NZ_CP034797:c4897378-4897187 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References