Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 428430..428901 Replicon chromosome
Accession NZ_CP034797
Organism Escherichia coli strain 08-3918

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag AYP37_RS02885 Protein ID WP_001303511.1
Coordinates 428623..428901 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag AYP37_RS02880 Protein ID WP_001302048.1
Coordinates 428430..428621 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AYP37_RS02840 423637..424221 - 585 WP_000206793.1 DUF551 domain-containing protein -
AYP37_RS02845 424278..424673 - 396 WP_001118159.1 DUF977 family protein -
AYP37_RS02850 424689..425458 - 770 Protein_431 DUF1627 domain-containing protein -
AYP37_RS02855 425484..426224 - 741 WP_000788938.1 ATP-binding protein -
AYP37_RS02860 426231..427193 - 963 WP_000095669.1 helix-turn-helix domain-containing protein -
AYP37_RS02865 427216..427641 - 426 WP_000693943.1 Rha family transcriptional regulator -
AYP37_RS02870 427638..427940 - 303 WP_000172738.1 transcriptional regulator -
AYP37_RS02875 428038..428409 + 372 WP_001169686.1 hypothetical protein -
AYP37_RS02880 428430..428621 + 192 WP_001302048.1 hypothetical protein Antitoxin
AYP37_RS02885 428623..428901 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AYP37_RS02890 429253..429552 + 300 WP_001240334.1 hypothetical protein -
AYP37_RS02895 429624..429842 + 219 WP_001171930.1 hypothetical protein -
AYP37_RS02905 430411..430599 + 189 WP_000449192.1 cell division inhibition protein DicB -
AYP37_RS02910 430596..430787 + 192 WP_001090200.1 DUF1482 family protein -
AYP37_RS02915 430880..433351 + 2472 WP_000048458.1 exonuclease -
AYP37_RS02920 433424..433675 + 252 WP_000005552.1 excisionase family protein -
AYP37_RS02925 433710..433894 + 185 Protein_445 DUF3596 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 339025..437187 98162


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T116646 WP_001303511.1 NZ_CP034797:428623-428901 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T116646 NZ_CP034797:428623-428901 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT116646 WP_001302048.1 NZ_CP034797:428430-428621 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT116646 NZ_CP034797:428430-428621 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References