Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 5308644..5309194 | Replicon | chromosome |
Accession | NZ_CP034794 | ||
Organism | Escherichia coli strain 06-3462 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D3H432 |
Locus tag | A1D74_RS27075 | Protein ID | WP_001160975.1 |
Coordinates | 5308880..5309194 (+) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | A1D74_RS27070 | Protein ID | WP_000125566.1 |
Coordinates | 5308644..5308877 (+) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
A1D74_RS27045 | 5303718..5304005 | + | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
A1D74_RS27050 | 5304063..5305394 | + | 1332 | WP_001183177.1 | MFS transporter | - |
A1D74_RS27055 | 5305502..5306032 | + | 531 | WP_000600700.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
A1D74_RS27060 | 5306025..5307887 | + | 1863 | WP_000377184.1 | glutathione-regulated potassium-efflux system protein KefC | - |
A1D74_RS27065 | 5308079..5308558 | + | 480 | WP_000624372.1 | type 3 dihydrofolate reductase | - |
A1D74_RS27070 | 5308644..5308877 | + | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
A1D74_RS27075 | 5308880..5309194 | + | 315 | WP_001160975.1 | CcdB family protein | Toxin |
A1D74_RS27080 | 5309191..5310039 | - | 849 | WP_000257187.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
A1D74_RS27085 | 5310046..5310423 | - | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
A1D74_RS27090 | 5310426..5311247 | - | 822 | WP_001065380.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
A1D74_RS27095 | 5311244..5312233 | - | 990 | WP_000241259.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
A1D74_RS27100 | 5312233..5313519 | - | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.76 Da Isoelectric Point: 9.8517
>T116638 WP_001160975.1 NZ_CP034794:5308880-5309194 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T116638 NZ_CP034794:5308880-5309194 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT116638 WP_000125566.1 NZ_CP034794:5308644-5308877 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT116638 NZ_CP034794:5308644-5308877 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|