Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 5059526..5060121 Replicon chromosome
Accession NZ_CP034794
Organism Escherichia coli strain 06-3462

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag A1D74_RS26020 Protein ID WP_000239579.1
Coordinates 5059771..5060121 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag A1D74_RS26015 Protein ID WP_001223210.1
Coordinates 5059526..5059777 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1D74_RS26005 5055191..5058970 + 3780 WP_000060930.1 autotransporter assembly complex protein TamB -
A1D74_RS26010 5058973..5059314 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
A1D74_RS26015 5059526..5059777 + 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
A1D74_RS26020 5059771..5060121 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
A1D74_RS26025 5060201..5060731 - 531 WP_000055075.1 inorganic diphosphatase -
A1D74_RS26030 5061041..5061997 + 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
A1D74_RS26035 5062137..5063639 + 1503 Protein_4924 sugar ABC transporter ATP-binding protein -
A1D74_RS26040 5063653..5064675 + 1023 WP_001301928.1 ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T116633 WP_000239579.1 NZ_CP034794:5059771-5060121 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T116633 NZ_CP034794:5059771-5060121 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT116633 WP_001223210.1 NZ_CP034794:5059526-5059777 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT116633 NZ_CP034794:5059526-5059777 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8


Antitoxin

Source ID Structure

References