Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 977219..977697 Replicon chromosome
Accession NZ_CP034794
Organism Escherichia coli strain 06-3462

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag A1D74_RS04675 Protein ID WP_001303876.1
Coordinates 977219..977506 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag A1D74_RS04680 Protein ID WP_000536233.1
Coordinates 977506..977697 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1D74_RS04635 972380..974851 - 2472 WP_000034474.1 exonuclease -
A1D74_RS04640 974945..975136 - 192 WP_001098307.1 DUF1482 family protein -
A1D74_RS04645 975133..975321 - 189 WP_000413705.1 cell division inhibition protein DicB -
A1D74_RS04655 975883..976068 + 186 WP_001133046.1 hypothetical protein -
A1D74_RS04660 976255..976644 - 390 WP_000394511.1 hypothetical protein -
A1D74_RS04665 976786..976941 - 156 WP_000379575.1 DUF1391 family protein -
A1D74_RS04675 977219..977506 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A1D74_RS04680 977506..977697 - 192 WP_000536233.1 hypothetical protein Antitoxin
A1D74_RS04685 977725..978126 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
A1D74_RS04690 978235..978507 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
A1D74_RS04695 978491..978916 + 426 WP_000693855.1 Rha family transcriptional regulator -
A1D74_RS04700 979123..979578 - 456 WP_000273724.1 hypothetical protein -
A1D74_RS04705 979657..980748 + 1092 WP_001205823.1 hypothetical protein -
A1D74_RS04710 980755..981501 + 747 WP_000788745.1 ATP-binding protein -
A1D74_RS04715 981523..982293 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116608 WP_001303876.1 NZ_CP034794:c977506-977219 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116608 NZ_CP034794:c977506-977219 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116608 WP_000536233.1 NZ_CP034794:c977697-977506 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116608 NZ_CP034794:c977697-977506 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References