Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2529754..2530232 Replicon chromosome
Accession NZ_CP034792
Organism Escherichia coli strain 2009C-3378

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag DR788_RS13580 Protein ID WP_001303876.1
Coordinates 2529945..2530232 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag DR788_RS13575 Protein ID WP_000536233.1
Coordinates 2529754..2529945 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR788_RS13540 2525158..2525928 - 771 WP_000450992.1 DUF1627 domain-containing protein -
DR788_RS13545 2525950..2526696 - 747 WP_000788745.1 ATP-binding protein -
DR788_RS13550 2526703..2527794 - 1092 WP_001205823.1 hypothetical protein -
DR788_RS13555 2527873..2528328 + 456 WP_000273724.1 hypothetical protein -
DR788_RS13560 2528535..2528960 - 426 WP_000693855.1 Rha family transcriptional regulator -
DR788_RS13565 2528944..2529216 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
DR788_RS13570 2529325..2529726 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
DR788_RS13575 2529754..2529945 + 192 WP_000536233.1 hypothetical protein Antitoxin
DR788_RS13580 2529945..2530232 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DR788_RS13590 2530510..2530665 + 156 WP_000379575.1 DUF1391 family protein -
DR788_RS13595 2530807..2531196 + 390 WP_000394511.1 hypothetical protein -
DR788_RS13600 2531383..2531568 - 186 WP_001133046.1 hypothetical protein -
DR788_RS13610 2532142..2532330 + 189 WP_000413705.1 cell division inhibition protein DicB -
DR788_RS13615 2532327..2532518 + 192 WP_001098307.1 DUF1482 family protein -
DR788_RS13620 2532612..2535083 + 2472 WP_000034474.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T116586 WP_001303876.1 NZ_CP034792:2529945-2530232 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T116586 NZ_CP034792:2529945-2530232 [Escherichia coli]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT116586 WP_000536233.1 NZ_CP034792:2529754-2529945 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT116586 NZ_CP034792:2529754-2529945 [Escherichia coli]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References