Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1679652..1680123 Replicon chromosome
Accession NZ_CP034792
Organism Escherichia coli strain 2009C-3378

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag DR788_RS08805 Protein ID WP_001303511.1
Coordinates 1679652..1679930 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag DR788_RS08810 Protein ID WP_001302048.1
Coordinates 1679932..1680123 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR788_RS08775 1676587..1677672 - 1086 Protein_1664 exonuclease -
DR788_RS08780 1677765..1677956 - 192 WP_001090200.1 DUF1482 family protein -
DR788_RS08785 1677953..1678141 - 189 WP_000449192.1 cell division inhibition protein DicB -
DR788_RS08795 1678710..1678928 - 219 WP_001171930.1 hypothetical protein -
DR788_RS08800 1679000..1679299 - 300 WP_001240334.1 hypothetical protein -
DR788_RS08805 1679652..1679930 - 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DR788_RS08810 1679932..1680123 - 192 WP_001302048.1 hypothetical protein Antitoxin
DR788_RS08815 1680144..1680515 - 372 WP_001169686.1 hypothetical protein -
DR788_RS08820 1680613..1680915 + 303 WP_000172738.1 transcriptional regulator -
DR788_RS08825 1680912..1681337 + 426 WP_000693943.1 Rha family transcriptional regulator -
DR788_RS08830 1681360..1682322 + 963 WP_000095669.1 helix-turn-helix domain-containing protein -
DR788_RS08835 1682329..1683069 + 741 WP_000788938.1 ATP-binding protein -
DR788_RS08840 1683095..1683864 + 770 Protein_1676 DUF1627 domain-containing protein -
DR788_RS08845 1683880..1684275 + 396 WP_001118159.1 DUF977 family protein -
DR788_RS08850 1684332..1684916 + 585 WP_000206793.1 DUF551 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - nleG7' 1671178..1769418 98240


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T116580 WP_001303511.1 NZ_CP034792:c1679930-1679652 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

>T116580 NZ_CP034792:c1679930-1679652 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT116580 WP_001302048.1 NZ_CP034792:c1680123-1679932 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp

>AT116580 NZ_CP034792:c1680123-1679932 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References