Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3689948..3690746 Replicon chromosome
Accession NZ_CP034787
Organism Escherichia coli strain ECCNB20-2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A166U9J9
Locus tag CRG85_RS17980 Protein ID WP_000854695.1
Coordinates 3689948..3690325 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2U2UUE3
Locus tag CRG85_RS17985 Protein ID WP_016243360.1
Coordinates 3690372..3690746 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CRG85_RS17950 3685226..3686182 + 957 WP_077491620.1 molybdenum cofactor insertion chaperone PaoD -
CRG85_RS17955 3686233..3686571 + 339 Protein_3450 LysR family transcriptional regulator -
CRG85_RS17960 3686909..3688228 + 1320 WP_000144689.1 site-specific integrase -
CRG85_RS17965 3688321..3689169 - 849 WP_001280536.1 DUF4942 domain-containing protein -
CRG85_RS17970 3689254..3689451 - 198 WP_000839228.1 DUF957 domain-containing protein -
CRG85_RS17975 3689463..3689951 - 489 WP_000761710.1 hypothetical protein -
CRG85_RS17980 3689948..3690325 - 378 WP_000854695.1 TA system toxin CbtA family protein Toxin
CRG85_RS17985 3690372..3690746 - 375 WP_016243360.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CRG85_RS17990 3690909..3691130 - 222 WP_000692307.1 DUF987 domain-containing protein -
CRG85_RS17995 3691199..3691675 - 477 WP_001186726.1 RadC family protein -
CRG85_RS18000 3691691..3692176 - 486 WP_000214414.1 antirestriction protein -
CRG85_RS18005 3692268..3693086 - 819 WP_113387975.1 DUF945 domain-containing protein -
CRG85_RS18010 3693177..3693410 - 234 WP_001117568.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagX/ecpC / yagW/ecpD / yagV/ecpE 3661044..3692176 31132


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14062.03 Da        Isoelectric Point: 7.7531

>T116561 WP_000854695.1 NZ_CP034787:c3690325-3689948 [Escherichia coli]
MKTLPDTHVREASCCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPGAKQ

Download         Length: 378 bp

>T116561 NZ_CP034787:c3690325-3689948 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGCACCGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCCCGCCGGGCGACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13810.66 Da        Isoelectric Point: 7.0266

>AT116561 WP_016243360.1 NZ_CP034787:c3690746-3690372 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT116561 NZ_CP034787:c3690746-3690372 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGAGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A166U9J9

Antitoxin

Source ID Structure
AlphaFold DB A0A2U2UUE3

References