Detailed information of TA system TA116517

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5429685..5430311
• Replicon: chromosome
• Accession: NZ_CP034783
• Organism: Pseudomonas sp. MPC6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ELQ88_RS27160
• Protein ID: WP_138968871.1
• Coordinates: 5429685..5429864 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ELQ88_RS27165
• Protein ID: WP_138968873.1
• Coordinates: 5429904..5430311 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELQ88_RS27140	5424883..5425950	-	1068	WP_128870745.1	hypothetical protein	-
ELQ88_RS27145	5426021..5427301	-	1281	WP_138968867.1	LssY C-terminal domain-containing protein	-
ELQ88_RS27150	5427298..5428590	-	1293	WP_138968869.1	LssY C-terminal domain-containing protein	-
ELQ88_RS27160	5429685..5429864	+	180	WP_138968871.1	type II toxin-antitoxin system HicA family toxin	Toxin
ELQ88_RS27165	5429904..5430311	+	408	WP_138968873.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ELQ88_RS27170	5430417..5431187	-	771	WP_138968875.1	trans-aconitate 2-methyltransferase	-
ELQ88_RS34200	5431301..5431453	+	153	WP_161599987.1	hypothetical protein	-
ELQ88_RS27175	5431645..5432730	-	1086	WP_138968877.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
ELQ88_RS27180	5432989..5433399	+	411	WP_128870727.1	low affinity iron permease family protein	-
ELQ88_RS27185	5433456..5433959	-	504	WP_128870726.1	DUF4142 domain-containing protein	-
ELQ88_RS27190	5434034..5434192	-	159	WP_082930399.1	stress protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5379735..5432730	52995

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6764.05 Da
• Isoelectric Point: 11.4113

>T116517 WP_138968871.1 NZ_CP034783:5429685-5429864 [Pseudomonas sp. MPC6]
VNSRFLINQIMADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL

Nucleotide

• Length: 180 bp

>T116517 NZ_CP034783:5429685-5429864 [Pseudomonas sp. MPC6]
GTGAATAGCCGATTTTTGATAAACCAAATCATGGCGGACGGTTGGTATCTGGTGCGGATCAGGGGTAGTCATCATCATTT
CAAGCACCCTACCAAGCCTGGCCTTGTGACCGTTCCACACCCTAAAAAAGATCTGCTCAAAAAAACAGCTATCAGTATTT
TGCAACAAGCACTGCTCTGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14607.64 Da
• Isoelectric Point: 4.4904

>AT116517 WP_138968873.1 NZ_CP034783:5429904-5430311 [Pseudomonas sp. MPC6]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGAPIPSANKVTLHAANPKYAGCTWAL
VDIDVTKYLGKAQKLNITLPGYLLTRIDEYVLHHPEEKSRSGFLASAALKVLQQG

Nucleotide

• Length: 408 bp

>AT116517 NZ_CP034783:5429904-5430311 [Pseudomonas sp. MPC6]
ATGCTTTACCCTATTGCGATATCGATGGGCGACGACGAACACGCCTGGGGCGTAGAAGTACCGGATATTCCCGGCTGTTT
CTCGGCCGGTGAAGATTTGGACGACGCCATGGCCATGGCCCGCGAAGCCATTGAAGGTCACTTCGAGATCCTGGCCGAGG
ATGGCGCGCCGATTCCATCAGCCAACAAAGTCACTCTGCATGCGGCCAATCCTAAATACGCCGGATGTACGTGGGCATTG
GTGGATATAGATGTCACCAAATACCTGGGCAAAGCCCAGAAGCTCAACATTACCCTGCCCGGCTATCTACTGACCCGGAT
TGACGAGTACGTGTTGCATCATCCGGAAGAGAAAAGCCGCTCCGGATTTCTGGCCTCGGCTGCACTCAAGGTGTTGCAGC
AGGGCTGA