Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3787222..3787879 Replicon chromosome
Accession NZ_CP034769
Organism Enterobacter sp. N18-03635

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag ELK40_RS18820 Protein ID WP_021242050.1
Coordinates 3787222..3787632 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag ELK40_RS18825 Protein ID WP_006178375.1
Coordinates 3787613..3787879 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELK40_RS18800 3783215..3784948 - 1734 WP_127732240.1 single-stranded-DNA-specific exonuclease RecJ -
ELK40_RS18805 3784954..3785667 - 714 WP_111963201.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ELK40_RS18810 3785696..3786592 - 897 WP_111963202.1 site-specific tyrosine recombinase XerD -
ELK40_RS18815 3786694..3787215 + 522 WP_008499710.1 flavodoxin FldB -
ELK40_RS18820 3787222..3787632 - 411 WP_021242050.1 protein YgfX Toxin
ELK40_RS18825 3787613..3787879 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
ELK40_RS18830 3788174..3789154 + 981 WP_127732242.1 tRNA-modifying protein YgfZ -
ELK40_RS18835 3789239..3789898 - 660 WP_127732244.1 hemolysin III family protein -
ELK40_RS18840 3790064..3790375 - 312 WP_127732246.1 N(4)-acetylcytidine aminohydrolase -
ELK40_RS18845 3790427..3791158 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
ELK40_RS18850 3791275..3792708 + 1434 WP_115876233.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T116485 WP_021242050.1 NZ_CP034769:c3787632-3787222 [Enterobacter sp. N18-03635]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T116485 NZ_CP034769:c3787632-3787222 [Enterobacter sp. N18-03635]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTAAGCTATACGCCGCTGTGGCTGCTGTTACTCTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGAATTAATGCCCGTCAGGGAGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGACCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT116485 WP_006178375.1 NZ_CP034769:c3787879-3787613 [Enterobacter sp. N18-03635]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT116485 NZ_CP034769:c3787879-3787613 [Enterobacter sp. N18-03635]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACTTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGATACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References