Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1065466..1066086 Replicon chromosome
Accession NZ_CP034769
Organism Enterobacter sp. N18-03635

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag ELK40_RS05750 Protein ID WP_008499287.1
Coordinates 1065466..1065684 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag ELK40_RS05755 Protein ID WP_008499288.1
Coordinates 1065712..1066086 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELK40_RS05720 1061481..1061741 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
ELK40_RS05725 1061744..1061884 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
ELK40_RS05730 1061881..1062591 - 711 WP_127729795.1 GNAT family N-acetyltransferase -
ELK40_RS05735 1062693..1064153 + 1461 WP_127729797.1 PLP-dependent aminotransferase family protein -
ELK40_RS05740 1064125..1064592 - 468 WP_023310598.1 hypothetical protein -
ELK40_RS05745 1064710..1065261 - 552 WP_023310599.1 maltose O-acetyltransferase -
ELK40_RS05750 1065466..1065684 - 219 WP_008499287.1 hemolysin expression modulator Hha Toxin
ELK40_RS05755 1065712..1066086 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
ELK40_RS05760 1066597..1069743 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit -
ELK40_RS05765 1069766..1070959 - 1194 WP_045909753.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T116475 WP_008499287.1 NZ_CP034769:c1065684-1065466 [Enterobacter sp. N18-03635]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T116475 NZ_CP034769:c1065684-1065466 [Enterobacter sp. N18-03635]
ATGTCTGATAAACCACTCACAAAGATCGATTATTTGATGCGCTTACGACGTTGTCAGTCAATTGACACGCTTGAACGCGT
CATTGAAAAGAATAAATACGAGCTTTCTGATAATGAACTGGCGGTATTTTATTCAGCCGCTGACCATCGTCTTGCTGAAC
TAACAATGAATAAGCTGTATGACAAAATCCCTACTTCTGTGTGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT116475 WP_008499288.1 NZ_CP034769:c1066086-1065712 [Enterobacter sp. N18-03635]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT116475 NZ_CP034769:c1066086-1065712 [Enterobacter sp. N18-03635]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGATGAAAGTAACCATGGCTGGGTAAACGATCCAACGTCTGCCATCAATTTACAGTTGAATGAGCTGATAGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTCATTGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCTCAGGATTTGCAAAAATGGCGTAAATCGGGAAATCGGCT
ATTCCGCTGTTTCGTCAACGTGAGCAGAGCTAACCCGGTGAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References