Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3881327..3881984 Replicon chromosome
Accession NZ_CP034754
Organism Enterobacter hormaechei subsp. hoffmannii strain Eh1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag EM861_RS18690 Protein ID WP_022649305.1
Coordinates 3881327..3881737 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag EM861_RS18695 Protein ID WP_003863437.1
Coordinates 3881718..3881984 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM861_RS18670 3877325..3879058 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
EM861_RS18675 3879064..3879777 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EM861_RS18680 3879806..3880702 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
EM861_RS18685 3880804..3881325 + 522 WP_015571793.1 flavodoxin FldB -
EM861_RS18690 3881327..3881737 - 411 WP_022649305.1 protein YgfX Toxin
EM861_RS18695 3881718..3881984 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
EM861_RS18700 3882279..3883259 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
EM861_RS18705 3883783..3884442 - 660 WP_022649307.1 hemolysin III family protein -
EM861_RS18710 3884709..3885440 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T116449 WP_022649305.1 NZ_CP034754:c3881737-3881327 [Enterobacter hormaechei subsp. hoffmannii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T116449 NZ_CP034754:c3881737-3881327 [Enterobacter hormaechei subsp. hoffmannii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT116449 WP_003863437.1 NZ_CP034754:c3881984-3881718 [Enterobacter hormaechei subsp. hoffmannii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT116449 NZ_CP034754:c3881984-3881718 [Enterobacter hormaechei subsp. hoffmannii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References