Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3600993..3601732 Replicon chromosome
Accession NZ_CP034754
Organism Enterobacter hormaechei subsp. hoffmannii strain Eh1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A431SEP0
Locus tag EM861_RS17365 Protein ID WP_022649088.1
Coordinates 3601352..3601732 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A431SER1
Locus tag EM861_RS17360 Protein ID WP_022649087.1
Coordinates 3600993..3601319 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM861_RS17345 3596887..3599547 - 2661 WP_022649084.1 hypothetical protein -
EM861_RS17350 3600081..3600500 + 420 Protein_3399 antirestriction protein -
EM861_RS17355 3600515..3600982 + 468 WP_022649086.1 DNA repair protein RadC -
EM861_RS17360 3600993..3601319 + 327 WP_022649087.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EM861_RS17365 3601352..3601732 + 381 WP_022649088.1 TA system toxin CbtA family protein Toxin
EM861_RS17370 3601729..3601956 + 228 WP_022649089.1 hypothetical protein -
EM861_RS17375 3602348..3602641 + 294 WP_022649090.1 hypothetical protein -
EM861_RS17380 3602985..3604301 - 1317 WP_022649091.1 amidase -
EM861_RS17385 3604356..3605651 - 1296 WP_022649092.1 histidinol dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3577884..3602641 24757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13850.66 Da        Isoelectric Point: 5.8788

>T116448 WP_022649088.1 NZ_CP034754:3601352-3601732 [Enterobacter hormaechei subsp. hoffmannii]
MQTLPLPEPRAAEPCPSPVQVWQLLLTHLLDKHYGLTLNDTPFGDDGVIQAHINAGISLCDAVNFIVERYELLRTDHSSS
SLTEHSSLIGAIDILRAHRATGLIVGSGYSTITRITTGQYREDKTQ

Download         Length: 381 bp

>T116448 NZ_CP034754:3601352-3601732 [Enterobacter hormaechei subsp. hoffmannii]
ATGCAAACTTTACCGTTACCCGAACCTCGGGCGGCTGAGCCATGTCCGTCGCCCGTGCAGGTCTGGCAACTCCTGCTCAC
GCATCTGCTGGATAAGCATTATGGTCTCACACTCAATGACACGCCGTTTGGCGACGACGGCGTAATTCAGGCGCACATCA
ACGCCGGTATCTCTCTGTGCGACGCCGTCAACTTCATTGTGGAAAGGTATGAACTGTTGCGCACTGACCACAGCAGCTCC
AGCCTCACCGAGCACTCTTCACTGATTGGTGCCATCGACATCCTGCGTGCCCACCGTGCAACCGGCCTGATAGTGGGCAG
CGGCTACAGCACCATCACCCGCATCACAACGGGCCAGTATCGGGAGGACAAAACACAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11923.47 Da        Isoelectric Point: 5.8762

>AT116448 WP_022649087.1 NZ_CP034754:3600993-3601319 [Enterobacter hormaechei subsp. hoffmannii]
MHSEQWGLTCGKTPCFSAKLVQEGNRLHFLADRAEFSGDLSDDEALRLDQAFPVILKQLEQMLSAGELNPRHQHRVTLHL
NGLTCEADTLGSHGYLYIAIYPSAVATG

Download         Length: 327 bp

>AT116448 NZ_CP034754:3600993-3601319 [Enterobacter hormaechei subsp. hoffmannii]
ATGCATTCTGAACAATGGGGACTGACGTGCGGTAAAACGCCGTGCTTCAGTGCCAAGCTGGTGCAGGAAGGCAACCGGCT
GCACTTTCTAGCTGACCGAGCAGAGTTTAGTGGCGACTTGAGCGACGATGAGGCACTGCGCCTCGACCAGGCTTTTCCGG
TGATATTGAAGCAGCTGGAACAAATGCTTTCAGCCGGTGAGCTGAATCCCCGCCATCAGCATCGCGTCACTCTGCATCTT
AACGGGCTAACCTGCGAAGCCGACACGCTCGGTTCGCACGGCTACCTTTACATCGCGATTTATCCCTCAGCGGTAGCTAC
CGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431SEP0

Antitoxin

Source ID Structure
AlphaFold DB A0A431SER1

References