Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1115825..1116446 Replicon chromosome
Accession NZ_CP034754
Organism Enterobacter hormaechei subsp. hoffmannii strain Eh1

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag EM861_RS05385 Protein ID WP_015571250.1
Coordinates 1115825..1116043 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag EM861_RS05390 Protein ID WP_006809850.1
Coordinates 1116072..1116446 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM861_RS05355 1111837..1112097 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
EM861_RS05360 1112100..1112240 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EM861_RS05365 1112237..1112947 - 711 WP_022647267.1 GNAT family N-acetyltransferase -
EM861_RS05370 1113050..1114510 + 1461 WP_022647268.1 PLP-dependent aminotransferase family protein -
EM861_RS05375 1114482..1114949 - 468 WP_022647269.1 hypothetical protein -
EM861_RS05380 1115066..1115617 - 552 WP_022647270.1 maltose O-acetyltransferase -
EM861_RS05385 1115825..1116043 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
EM861_RS05390 1116072..1116446 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
EM861_RS05395 1116956..1120102 - 3147 WP_022647271.1 multidrug efflux RND transporter permease subunit -
EM861_RS05400 1120125..1121318 - 1194 WP_022647272.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T116438 WP_015571250.1 NZ_CP034754:c1116043-1115825 [Enterobacter hormaechei subsp. hoffmannii]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T116438 NZ_CP034754:c1116043-1115825 [Enterobacter hormaechei subsp. hoffmannii]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT116438 WP_006809850.1 NZ_CP034754:c1116446-1116072 [Enterobacter hormaechei subsp. hoffmannii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT116438 NZ_CP034754:c1116446-1116072 [Enterobacter hormaechei subsp. hoffmannii]
TTGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References