Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 636324..636965 Replicon chromosome
Accession NZ_CP034752
Organism Jinshanibacter zhutongyuii strain CF-458

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EKN56_RS02410 Protein ID WP_130590345.1
Coordinates 636324..636506 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EKN56_RS02415 Protein ID WP_130590346.1
Coordinates 636525..636965 (+) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN56_RS02380 631460..632866 + 1407 WP_130590340.1 PTS ascorbate transporter subunit IIC -
EKN56_RS02385 632885..633190 + 306 WP_130590341.1 PTS ascorbate transporter subunit IIB -
EKN56_RS02390 633201..633659 + 459 WP_130590342.1 PTS ascorbate transporter subunit IIA -
EKN56_RS02395 633708..634364 + 657 WP_168189582.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
EKN56_RS02400 634374..635234 + 861 WP_130590343.1 L-ribulose-5-phosphate 3-epimerase -
EKN56_RS02405 635234..635920 + 687 WP_130590344.1 L-ribulose-5-phosphate 4-epimerase -
EKN56_RS02410 636324..636506 + 183 WP_130590345.1 type II toxin-antitoxin system HicA family toxin Toxin
EKN56_RS02415 636525..636965 + 441 WP_130590346.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EKN56_RS02420 637005..637934 - 930 WP_130590347.1 2-dehydropantoate 2-reductase -
EKN56_RS02425 638170..638895 + 726 WP_130590348.1 phosphatase PAP2 family protein -
EKN56_RS02430 638911..639498 + 588 WP_130590349.1 undecaprenyl-diphosphate phosphatase -
EKN56_RS02435 639955..641118 + 1164 WP_130590350.1 collagen-like triple helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6831.93 Da        Isoelectric Point: 11.6502

>T116434 WP_130590345.1 NZ_CP034752:636324-636506 [Jinshanibacter zhutongyuii]
MKSSDLIKDLRAAGCEWRRHNGGSHQIWWSPITKKTFPVPHPKKNLPEGTIRSIRRAAGI

Download         Length: 183 bp

>T116434 NZ_CP034752:636324-636506 [Jinshanibacter zhutongyuii]
ATGAAATCATCGGATTTGATTAAAGATCTTCGGGCTGCCGGGTGTGAATGGCGGCGCCATAATGGAGGAAGTCATCAGAT
ATGGTGGTCTCCAATAACAAAAAAGACATTTCCAGTACCTCATCCTAAAAAGAATTTGCCTGAGGGAACGATTAGATCGA
TCAGAAGAGCGGCTGGAATTTAG

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16514.59 Da        Isoelectric Point: 4.2039

>AT116434 WP_130590346.1 NZ_CP034752:636525-636965 [Jinshanibacter zhutongyuii]
MLFSIAVEVPQDEQTAYGLTVPALCNENYGCFSAADQIEDVAGMAREAILLTITDMIESGNYALEHINDRGPLVYQNTHP
EFDGQQWFVIEVDLSELEGKPQRINISLPDVLIRRIDSRVKTQEDYRDRSHFLAVAAKNELLRMEG

Download         Length: 441 bp

>AT116434 NZ_CP034752:636525-636965 [Jinshanibacter zhutongyuii]
ATGTTATTTTCTATTGCTGTTGAAGTACCACAGGATGAACAGACGGCTTATGGGCTGACGGTGCCTGCATTATGTAATGA
AAACTATGGATGTTTTTCAGCGGCAGACCAGATAGAAGATGTCGCCGGAATGGCTCGGGAAGCCATCTTACTAACCATCA
CAGATATGATTGAATCAGGAAATTATGCGCTGGAGCATATTAACGATCGTGGCCCGTTAGTTTATCAGAATACGCACCCT
GAATTTGACGGGCAACAATGGTTCGTGATTGAGGTTGATTTATCTGAGCTGGAAGGAAAGCCACAGCGGATTAATATTTC
TCTACCGGATGTGCTAATTCGTCGAATTGATTCGCGCGTTAAAACTCAGGAAGATTACCGTGACCGCAGCCATTTTTTGG
CCGTTGCAGCAAAAAATGAATTATTAAGGATGGAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References