Detailed information of TA system TA116407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 104110..105678
• Replicon: plasmid pRSE15
• Accession: NZ_CP034714
• Organism: Salmonella enterica subsp. enterica serovar Mikawasima strain RSE15

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: ELZ82_RS23800
• Protein ID: WP_063942021.1
• Coordinates: 104371..105678 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A859R2S1
• Locus tag: ELZ82_RS23795
• Protein ID: WP_039272366.1
• Coordinates: 104110..104361 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELZ82_RS23765	99664..100047	+	384	WP_023356362.1	hypothetical protein	-
ELZ82_RS23770	100528..100980	+	453	WP_023356364.1	hypothetical protein	-
ELZ82_RS23775	100996..101598	-	603	WP_012766356.1	hypothetical protein	-
ELZ82_RS23780	101859..102140	+	282	WP_164732588.1	hypothetical protein	-
ELZ82_RS23785	102159..102722	+	564	WP_101778855.1	hypothetical protein	-
ELZ82_RS23790	102725..103729	+	1005	WP_063942013.1	tyrosine-type recombinase/integrase	-
ELZ82_RS23795	104110..104361	+	252	WP_039272366.1	helix-turn-helix domain-containing protein	Antitoxin
ELZ82_RS23800	104371..105678	+	1308	WP_063942021.1	type II toxin-antitoxin system HipA family toxin	Toxin
ELZ82_RS23805	105675..106169	+	495	WP_127173252.1	hypothetical protein	-
ELZ82_RS23810	106344..107282	-	939	WP_086598698.1	hypothetical protein	-
ELZ82_RS23815	107481..109121	+	1641	WP_086598699.1	PAAR domain-containing protein	-
ELZ82_RS23825	109520..109819	-	300	WP_012766365.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..126510	126510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 55901.92 Da
• Isoelectric Point: 13.4384

>T116407 WP_063942021.1 NZ_CP034714:104371-105678 [Salmonella enterica subsp. enterica serovar Mikawasima]
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Nucleotide

• Length: 1308 bp

>T116407 NZ_CP034714:104371-105678 [Salmonella enterica subsp. enterica serovar Mikawasima]
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Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT116407 WP_039272366.1 NZ_CP034714:104110-104361 [Salmonella enterica subsp. enterica serovar Mikawasima]
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Nucleotide

• Length: 252 bp

>AT116407 NZ_CP034714:104110-104361 [Salmonella enterica subsp. enterica serovar Mikawasima]
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Structures

Antitoxin

• AlphaFold DB: A0A859R2S1