Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6615974..6617732 Replicon chromosome
Accession NZ_CP034689
Organism Achromobacter spanius strain UQ283

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag ELS24_RS30435 Protein ID WP_164741324.1
Coordinates 6615974..6616906 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ELS24_RS30440 Protein ID WP_127186503.1
Coordinates 6616920..6617732 (+) Length 271 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELS24_RS30410 6611425..6612192 - 768 WP_127186186.1 ABC transporter permease -
ELS24_RS30415 6612193..6612933 - 741 WP_050448339.1 ABC transporter ATP-binding protein -
ELS24_RS30420 6612974..6613981 - 1008 WP_164741323.1 ABC transporter substrate-binding protein -
ELS24_RS30425 6614061..6614660 - 600 WP_050448284.1 cupin domain-containing protein -
ELS24_RS30430 6614723..6615799 - 1077 WP_127186188.1 porin -
ELS24_RS30435 6615974..6616906 + 933 WP_164741324.1 alpha/beta hydrolase Toxin
ELS24_RS30440 6616920..6617732 + 813 WP_127186503.1 IclR family transcriptional regulator Antitoxin
ELS24_RS30445 6617765..6618574 + 810 WP_127186190.1 aspartate dehydrogenase -
ELS24_RS30450 6618681..6618992 - 312 WP_003806903.1 30S ribosomal protein S10 -
ELS24_RS30455 6619067..6620257 - 1191 WP_006221899.1 elongation factor Tu -
ELS24_RS30460 6620333..6622435 - 2103 WP_050450090.1 elongation factor G -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-292)

Antitoxin

Transcription regulator IclR, C-terminal

(130-252)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 32188.50 Da        Isoelectric Point: 7.2356

>T116406 WP_164741324.1 NZ_CP034689:6615974-6616906 [Achromobacter spanius]
MPTALTSSVSPTGSALGPDPTRALSARLEDLDKGFPLHQAPSAIGTLTYRSSGTGPAVVLLHGIGSAAGCWLDVALMLRD
GFRVIAWNAPGYAGSTPLPQAHPSADDYADALHQLLAHAGVSECVLVGHSLGAIVAGAYAARGAGNARVAIRRLVLLSPA
QGYASHDEAQREAVRTRRLTLLEAEGIEGIAAQRAAALLSNAATPAMREWASWNMRQISPTGYRQAVSLLCNSDLLSRPA
PAMPVDVRVGELDVITPAAQGQTVAQAWHASFAQIDGAGHACHIERPAQVAEIVRGSARNGGVKSELPFA

Download         Length: 933 bp

>T116406 NZ_CP034689:6615974-6616906 [Achromobacter spanius]
ATGCCCACTGCACTCACTTCTTCCGTGTCGCCAACGGGATCTGCCCTGGGGCCCGACCCGACGCGCGCCCTGTCCGCCCG
ACTTGAAGACCTGGATAAAGGCTTCCCTTTGCACCAGGCGCCCTCGGCGATCGGCACCCTCACCTACCGAAGCTCGGGCA
CCGGCCCCGCCGTGGTTTTGCTGCACGGCATCGGGTCTGCCGCCGGCTGCTGGCTGGATGTCGCGCTGATGTTGCGAGAC
GGGTTTCGTGTCATCGCCTGGAACGCGCCAGGCTATGCCGGTTCCACGCCGCTGCCCCAGGCGCATCCGTCGGCCGACGA
TTACGCCGACGCCTTGCATCAGTTGCTGGCGCACGCGGGAGTGTCGGAATGCGTGCTCGTGGGCCATTCCCTTGGCGCCA
TCGTGGCGGGCGCTTATGCGGCGCGCGGGGCCGGCAACGCGCGGGTCGCGATTCGGCGGCTGGTGCTGCTCAGTCCCGCC
CAAGGGTACGCAAGCCATGACGAGGCACAACGCGAGGCCGTACGCACGCGCCGCTTGACCTTATTGGAGGCAGAAGGCAT
CGAGGGCATCGCCGCGCAACGGGCTGCTGCATTGCTATCGAATGCGGCGACGCCGGCCATGCGGGAATGGGCGAGCTGGA
ACATGCGCCAGATTTCGCCGACCGGTTACCGCCAAGCGGTCAGCCTCCTGTGCAACAGCGACCTCCTGTCCCGTCCAGCA
CCCGCCATGCCGGTGGACGTGCGGGTGGGCGAGCTCGACGTCATCACGCCAGCCGCTCAAGGCCAAACCGTGGCACAAGC
CTGGCACGCTTCGTTTGCACAGATCGACGGCGCGGGCCACGCCTGCCATATCGAGCGTCCTGCACAAGTCGCCGAGATCG
TGCGCGGCTCGGCCAGGAACGGCGGCGTCAAGTCGGAGCTTCCCTTTGCTTGA

Antitoxin


Download         Length: 271 a.a.        Molecular weight: 29230.61 Da        Isoelectric Point: 7.0530

>AT116406 WP_127186503.1 NZ_CP034689:6616920-6617732 [Achromobacter spanius]
MQDKRYTVPALERGLRLLGEFSRQDRVLGAPELARRLNIPRSTVFRMLNTLETLGFVRKADGGAAYRLDTAVLRLGFEYL
ASLELTDLGRPLLERLRDATGYSTNLVVRDRRSAVVVAKVSAPTPFVSTVFVGTRLPTHATLLGRAVMCDLSLPELFDLY
GADPLPPHSAHTPRSVPALHALLQEDLARGYVIERGFYEAIVGSIAAPVRDASGRVIAALGVTIPTLSPEEPTIDEASVI
HAVCAAANELSASLDYVPPLAEHNVVSGRT

Download         Length: 813 bp

>AT116406 NZ_CP034689:6616920-6617732 [Achromobacter spanius]
ATGCAAGACAAGCGCTACACCGTACCGGCGCTTGAGCGAGGCTTGCGGCTACTGGGCGAGTTCAGCCGTCAAGATCGTGT
GCTGGGCGCCCCGGAATTGGCGCGTCGGTTGAACATTCCACGCTCGACCGTGTTCCGGATGTTGAACACACTCGAGACCC
TGGGTTTCGTCCGCAAGGCCGACGGCGGCGCGGCGTACAGGCTGGATACGGCCGTGCTGCGCCTGGGCTTTGAGTATCTG
GCGTCGCTGGAACTCACCGACCTGGGCCGGCCGTTGTTGGAACGCCTGCGTGACGCTACCGGCTATTCCACCAATCTGGT
GGTGCGCGACCGCCGCTCGGCGGTCGTCGTCGCCAAGGTCTCCGCGCCCACGCCCTTCGTCAGCACGGTCTTCGTCGGCA
CCCGCCTGCCGACCCATGCAACGCTGCTTGGCCGGGCGGTCATGTGCGACCTTTCCCTGCCCGAACTCTTTGATCTTTAT
GGCGCCGATCCCTTGCCGCCGCACTCAGCGCACACGCCGCGCAGCGTGCCCGCGCTACACGCCCTGCTTCAGGAAGATCT
GGCGAGAGGCTATGTGATTGAACGCGGATTCTATGAAGCTATCGTCGGCAGCATTGCGGCGCCCGTGCGCGATGCCAGCG
GCCGAGTCATCGCTGCGTTGGGCGTCACCATCCCCACCCTAAGCCCTGAAGAACCGACCATCGACGAAGCCTCCGTCATC
CACGCGGTATGCGCCGCTGCGAATGAACTGTCCGCCTCGCTCGATTATGTACCGCCATTGGCAGAGCACAACGTCGTCTC
TGGAAGGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References