Detailed information of TA system TA116405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 6090847..6091420
• Replicon: chromosome
• Accession: NZ_CP034689
• Organism: Achromobacter spanius strain UQ283

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ELS24_RS27845
• Protein ID: WP_127185978.1
• Coordinates: 6090847..6091134 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A3Q9KPF8
• Locus tag: ELS24_RS27850
• Protein ID: WP_050445865.1
• Coordinates: 6091121..6091420 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELS24_RS27830	6086488..6087507	-	1020	WP_127185976.1	tripartite tricarboxylate transporter substrate binding protein	-
ELS24_RS27835	6087692..6088477	-	786	WP_050445867.1	hydroxypyruvate isomerase family protein	-
ELS24_RS27840	6088608..6090731	-	2124	WP_127185977.1	TonB-dependent receptor	-
ELS24_RS27845	6090847..6091134	-	288	WP_127185978.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELS24_RS27850	6091121..6091420	-	300	WP_050445865.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ELS24_RS27855	6091643..6092122	+	480	WP_050445864.1	VOC family protein	-
ELS24_RS27860	6092184..6093233	-	1050	WP_050445863.1	ABC transporter substrate-binding protein	-
ELS24_RS27865	6093329..6094306	-	978	WP_127185979.1	GTP-binding protein	-
ELS24_RS27870	6094308..6095966	-	1659	WP_127185980.1	amidohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-51)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10833.51 Da
• Isoelectric Point: 8.4940

>T116405 WP_127185978.1 NZ_CP034689:c6091134-6090847 [Achromobacter spanius]
VPVLEWRETAREDLLAIVDYISDDSPAAALRLVDEIQKKVAKLRERPRLYRSGRVAGTREMVIRPNYLVVYAESPHAVTI
LRVLHAAQQWPLDSA

Nucleotide

• Length: 288 bp

>T116405 NZ_CP034689:c6091134-6090847 [Achromobacter spanius]
GTGCCGGTTCTTGAATGGCGCGAAACGGCTCGCGAGGATTTGCTGGCGATTGTCGATTACATCTCGGACGATAGCCCGGC
CGCGGCGCTGCGTTTGGTAGATGAAATTCAGAAGAAAGTGGCCAAGCTGCGTGAGCGCCCACGGCTGTATCGCTCGGGAC
GAGTAGCGGGCACCAGGGAAATGGTGATTCGGCCGAACTACTTGGTCGTGTATGCGGAATCGCCTCACGCCGTGACAATT
TTGCGCGTTCTGCACGCCGCACAGCAATGGCCGCTCGATAGCGCCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10654.37 Da
• Isoelectric Point: 10.1426

>AT116405 WP_050445865.1 NZ_CP034689:c6091420-6091121 [Achromobacter spanius]
MAPTSMLHVRVDDKLKAEAAEKLANVGLTISDAVRILLTRVAKEGGLPAGLAVDAMSYDSWFRAKVQEALADTRPPVAHE
AVMDEARALISKKKRRAGS

Nucleotide

• Length: 300 bp

>AT116405 NZ_CP034689:c6091420-6091121 [Achromobacter spanius]
ATGGCACCCACTTCAATGTTGCACGTCCGTGTCGACGACAAGCTCAAGGCCGAAGCGGCGGAAAAGCTCGCCAACGTTGG
CCTGACCATCTCGGATGCGGTGCGAATTTTGCTAACGAGAGTGGCAAAAGAAGGCGGTTTGCCCGCCGGCCTGGCCGTCG
ACGCCATGAGCTACGACTCGTGGTTTCGCGCGAAGGTGCAAGAGGCCTTGGCCGACACGCGGCCACCGGTCGCCCATGAA
GCGGTCATGGACGAGGCTCGTGCCCTGATCAGCAAGAAGAAGCGCCGTGCCGGTTCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A3Q9KPF8