Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 6009005..6009618 Replicon chromosome
Accession NZ_CP034689
Organism Achromobacter spanius strain UQ283

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag ELS24_RS27460 Protein ID WP_127186489.1
Coordinates 6009310..6009618 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag ELS24_RS27455 Protein ID WP_127185936.1
Coordinates 6009005..6009313 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELS24_RS27440 6005047..6006279 + 1233 WP_127185933.1 3-hydroxybenzoate 6-monooxygenase -
ELS24_RS27445 6006339..6007514 + 1176 WP_127185934.1 ABC transporter substrate-binding protein -
ELS24_RS27450 6007852..6008883 - 1032 WP_127185935.1 tripartite tricarboxylate transporter substrate binding protein -
ELS24_RS27455 6009005..6009313 - 309 WP_127185936.1 putative addiction module antidote protein Antitoxin
ELS24_RS27460 6009310..6009618 - 309 WP_127186489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELS24_RS27465 6009779..6010519 - 741 WP_050445733.1 amino acid ABC transporter ATP-binding protein -
ELS24_RS27470 6010580..6011680 - 1101 WP_050445601.1 amino acid ABC transporter permease -
ELS24_RS27475 6011682..6012872 - 1191 WP_050445600.1 amino acid ABC transporter permease -
ELS24_RS27480 6012997..6014013 - 1017 WP_050445599.1 amino acid ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11841.67 Da        Isoelectric Point: 10.8084

>T116404 WP_127186489.1 NZ_CP034689:c6009618-6009310 [Achromobacter spanius]
MLRFRETEAFTRWLNSLRDLRARAQILRRLSRAMNGNFGYVEPVGEGVSEMRVNIGAGYRVYYARADEVVYVLLCGGNKT
RQGKDIAQAKRLWTEIKRSIEK

Download         Length: 309 bp

>T116404 NZ_CP034689:c6009618-6009310 [Achromobacter spanius]
ATGCTTAGATTCCGAGAAACCGAGGCGTTCACCCGTTGGCTAAATTCACTCCGAGACTTGCGGGCGCGTGCTCAAATCCT
GCGCCGATTGTCGCGCGCCATGAATGGGAATTTTGGCTACGTAGAGCCAGTGGGCGAGGGCGTCAGTGAAATGCGCGTGA
ATATTGGCGCCGGCTACCGGGTGTACTACGCCCGAGCCGACGAGGTGGTCTACGTGCTGCTTTGCGGCGGAAACAAGACC
AGGCAGGGCAAAGACATTGCCCAAGCCAAACGCCTTTGGACGGAAATTAAGCGGAGCATCGAGAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11113.54 Da        Isoelectric Point: 6.4663

>AT116404 WP_127185936.1 NZ_CP034689:c6009313-6009005 [Achromobacter spanius]
MTKLRDFDAANYLKDDETIAHYLADAAAEDDPDAFLQALGDVARARGITEIARETGLARTNLYRVLAPGANPSYHTLRKV
MNALGVSLTALVRRKSEPTPQG

Download         Length: 309 bp

>AT116404 NZ_CP034689:c6009313-6009005 [Achromobacter spanius]
ATGACGAAATTACGCGACTTCGACGCAGCGAATTATTTGAAAGATGACGAAACGATCGCGCATTACCTGGCGGACGCGGC
GGCGGAGGACGATCCTGACGCCTTCCTGCAAGCCCTGGGCGACGTGGCGCGCGCGCGCGGCATCACTGAAATTGCTCGTG
AGACAGGGCTTGCCAGAACAAACCTGTATCGGGTGCTGGCCCCCGGCGCGAACCCCAGCTACCACACCCTGCGCAAGGTC
ATGAACGCACTAGGCGTTTCACTCACCGCGCTGGTCAGGCGCAAATCCGAACCCACGCCGCAAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References