Detailed information of TA system TA116403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HTH_37(antitoxin)
• Location: 4575391..4576059
• Replicon: chromosome
• Accession: NZ_CP034689
• Organism: Achromobacter spanius strain UQ283

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: ELS24_RS20850
• Protein ID: WP_127185230.1
• Coordinates: 4575391..4575576 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: ELS24_RS20855
• Protein ID: WP_127185231.1
• Coordinates: 4575646..4576059 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELS24_RS20825	4570398..4571138	-	741	WP_127185225.1	Clp protease ClpP	-
ELS24_RS20830	4571104..4572444	-	1341	WP_127185226.1	phage portal protein	-
ELS24_RS20835	4572444..4574144	-	1701	WP_127185227.1	terminase large subunit	-
ELS24_RS20840	4574191..4574511	-	321	WP_127185228.1	hypothetical protein	-
ELS24_RS30970	4574698..4574865	-	168	WP_164741277.1	hypothetical protein	-
ELS24_RS20845	4574865..4575197	-	333	WP_127185229.1	HNH endonuclease	-
ELS24_RS20850	4575391..4575576	+	186	WP_127185230.1	type II toxin-antitoxin system HicA family toxin	Toxin
ELS24_RS20855	4575646..4576059	+	414	WP_127185231.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ELS24_RS20860	4576073..4576435	+	363	WP_127185232.1	response regulator	-
ELS24_RS20865	4576469..4577239	-	771	WP_127185233.1	DNA adenine methylase	-
ELS24_RS20870	4577474..4578565	-	1092	WP_127185234.1	RelA/SpoT domain-containing protein	-
ELS24_RS20875	4578704..4579297	-	594	WP_127185235.1	hypothetical protein	-
ELS24_RS20880	4579294..4579665	-	372	WP_127185236.1	hypothetical protein	-
ELS24_RS20885	4579676..4580038	-	363	WP_127185237.1	hypothetical protein	-
ELS24_RS20890	4580074..4580268	-	195	WP_127185238.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4549429..4593916	44487

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6923.10 Da
• Isoelectric Point: 10.7422

>T116403 WP_127185230.1 NZ_CP034689:4575391-4575576 [Achromobacter spanius]
MKYSEFRRWLLKQGVKLEPHKSGSSHFKATLGDRIASFPDHGTKEIGKGLVEKIKKDLGLK

Nucleotide

• Length: 186 bp

>T116403 NZ_CP034689:4575391-4575576 [Achromobacter spanius]
ATGAAATACAGCGAGTTCAGGCGGTGGCTGCTGAAACAGGGCGTGAAGTTGGAACCCCACAAATCAGGTAGCAGCCACTT
CAAAGCAACCCTTGGCGATCGGATAGCAAGCTTTCCAGACCACGGCACCAAAGAGATAGGTAAAGGGCTGGTAGAGAAGA
TCAAAAAGGATCTTGGACTGAAGTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15000.04 Da
• Isoelectric Point: 4.5022

>AT116403 WP_127185231.1 NZ_CP034689:4575646-4576059 [Achromobacter spanius]
MLTYCYTLTPDTNGTNLIQYPDLPEGASVSEDEHDLPANASEGLEAVLQMYIDARRPIPLPEAVGDGSVTLGALPTAKVF
LSNEMVRQGVRKTELARRLGIHNPQVDRLLDLAHSSKLEAMEAAFQELGRRLDISVI

Nucleotide

• Length: 414 bp

>AT116403 NZ_CP034689:4575646-4576059 [Achromobacter spanius]
ATGTTGACCTACTGCTACACCCTGACGCCGGACACGAACGGCACGAACCTGATTCAGTATCCGGACCTGCCGGAAGGCGC
ATCCGTAAGCGAAGACGAGCACGACCTACCAGCCAACGCATCAGAAGGGCTTGAAGCCGTGCTACAGATGTACATCGACG
CGCGCCGCCCTATCCCGCTGCCTGAAGCCGTGGGCGACGGCAGCGTGACGCTAGGCGCACTGCCTACCGCAAAGGTCTTT
CTGTCAAACGAGATGGTGCGTCAAGGGGTGCGAAAAACCGAACTCGCGCGGCGACTCGGCATCCACAACCCCCAGGTTGA
CCGCCTTCTGGATCTGGCGCACAGTTCAAAGCTGGAAGCGATGGAGGCTGCGTTTCAAGAATTGGGTCGTCGCCTGGATA
TTTCTGTCATCTAA