Detailed information of TA system TA116402

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3686447..3687126
• Replicon: chromosome
• Accession: NZ_CP034689
• Organism: Achromobacter spanius strain UQ283

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3S9YWU0
• Locus tag: ELS24_RS16775
• Protein ID: WP_050446637.1
• Coordinates: 3686695..3687126 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ELS24_RS16770
• Protein ID: WP_127184763.1
• Coordinates: 3686447..3686698 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELS24_RS16750	3681759..3683663	-	1905	WP_127184759.1	NYN domain-containing protein	-
ELS24_RS16755	3683960..3684856	+	897	WP_127184760.1	MotA/TolQ/ExbB proton channel family protein	-
ELS24_RS16760	3684853..3685830	+	978	WP_127184761.1	OmpA family protein	-
ELS24_RS16765	3685993..3686346	+	354	WP_127184762.1	dehydrogenase	-
ELS24_RS16770	3686447..3686698	+	252	WP_127184763.1	Arc family DNA-binding protein	Antitoxin
ELS24_RS16775	3686695..3687126	+	432	WP_050446637.1	type II toxin-antitoxin system VapC family toxin	Toxin
ELS24_RS16780	3687250..3687660	+	411	WP_050446638.1	YciI family protein	-
ELS24_RS16785	3687679..3688086	+	408	WP_127184764.1	VOC family protein	-
ELS24_RS16790	3688083..3689357	+	1275	WP_127184765.1	RNA polymerase sigma factor	-
ELS24_RS16795	3689433..3690257	+	825	WP_127186370.1	AraC family transcriptional regulator	-
ELS24_RS16800	3690378..3691337	+	960	WP_127184766.1	DMT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• Arc-like DNA binding domain (10-46)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15099.37 Da
• Isoelectric Point: 5.5556

>T116402 WP_050446637.1 NZ_CP034689:3686695-3687126 [Achromobacter spanius]
MILLDTNVISEPLRQAPADAVIEWIDRQPLETLFLSAVTVAELRFGVACMPVGKRRDALHADLEQRVLALFAGRILAFDT
AASLEYAALMARARASGQAIGGPDGYIAATAAAHGMSVATRDVAPFEAAGVSVINPWGAHPPH

Nucleotide

• Length: 432 bp

>T116402 NZ_CP034689:3686695-3687126 [Achromobacter spanius]
ATGATTCTGCTGGACACCAATGTCATCTCGGAGCCGCTGCGCCAGGCGCCCGCCGACGCCGTCATCGAATGGATAGACCG
GCAGCCCCTGGAAACCTTGTTTCTTTCCGCCGTCACCGTCGCTGAATTGCGCTTTGGCGTGGCCTGCATGCCGGTGGGCA
AACGGCGCGACGCCTTGCATGCAGACCTGGAACAGCGCGTCCTGGCCTTGTTTGCTGGGCGCATCCTGGCTTTCGATACC
GCCGCCAGCCTGGAGTACGCCGCGCTGATGGCGCGTGCGCGGGCCTCGGGCCAGGCCATCGGCGGGCCAGACGGCTACAT
TGCCGCCACCGCCGCCGCGCACGGCATGAGCGTCGCGACCCGGGACGTGGCGCCCTTTGAAGCCGCCGGGGTTTCCGTCA
TCAACCCTTGGGGCGCGCATCCACCGCACTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9214.54 Da
• Isoelectric Point: 8.8737

>AT116402 WP_127184763.1 NZ_CP034689:3686447-3686698 [Achromobacter spanius]
MPMLTVRNISEEVHRALRVRAAQHGRSTEAEVRAILEDAVKPEGRVKLGSLLAQIGRQAKLTDEEAALFDQRDKAPAAPP
RFE

Nucleotide

• Length: 252 bp

>AT116402 NZ_CP034689:3686447-3686698 [Achromobacter spanius]
ATGCCTATGTTGACTGTGAGAAATATCTCTGAAGAAGTGCACCGCGCCCTGCGCGTGCGCGCCGCCCAGCATGGCCGAAG
CACCGAAGCCGAGGTCCGCGCCATTCTTGAAGACGCCGTCAAGCCTGAAGGGCGCGTCAAGCTGGGCTCGTTGCTTGCGC
AGATCGGCCGCCAGGCCAAGCTCACCGACGAGGAAGCCGCCTTGTTCGACCAACGCGACAAGGCGCCCGCCGCCCCACCG
AGGTTTGAATGA

Structures

Toxin

• AlphaFold DB: A0A3S9YWU0