Detailed information of TA system TA116395

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4870923..4871497
• Replicon: chromosome
• Accession: NZ_CP034688
• Organism: Pseudomonas citronellolis strain WXP-4

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1S1GEF4
• Locus tag: ELR50_RS21640
• Protein ID: WP_043268833.1
• Coordinates: 4871132..4871497 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: ELR50_RS21635
• Protein ID: WP_253392721.1
• Coordinates: 4870923..4871138 (+)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELR50_RS21615 (ELR50_21555)	4866014..4866805	+	792	WP_043318713.1	taurine ABC transporter ATP-binding protein	-
ELR50_RS21620 (ELR50_21560)	4866795..4867613	+	819	WP_269962280.1	ABC transporter permease subunit	-
ELR50_RS21625 (ELR50_21565)	4867805..4868641	+	837	WP_043268829.1	taurine dioxygenase	-
ELR50_RS21630 (ELR50_21570)	4868830..4870854	+	2025	WP_043268831.1	oligopeptide transporter, OPT family	-
ELR50_RS21635 (ELR50_21575)	4870923..4871138	+	216	WP_253392721.1	CopG family transcriptional regulator	Antitoxin
ELR50_RS21640 (ELR50_21580)	4871132..4871497	+	366	WP_043268833.1	type II toxin-antitoxin system VapC family toxin	Toxin
ELR50_RS21645 (ELR50_21585)	4871485..4872210	-	726	WP_269962281.1	hypothetical protein	-
ELR50_RS21650 (ELR50_21590)	4872207..4872389	-	183	WP_269962282.1	hypothetical protein	-
ELR50_RS21655 (ELR50_21595)	4872386..4873534	-	1149	WP_269962283.1	PepSY domain-containing protein	-
ELR50_RS21660 (ELR50_21600)	4873542..4875953	-	2412	WP_269962284.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-106)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-40)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13390.48 Da
• Isoelectric Point: 5.8613

>T116395 WP_043268833.1 NZ_CP034688:4871132-4871497 [Pseudomonas citronellolis]
MVKALFDTNILIDYLNGHEQARDELRRYDDPAISIVTWMEVMIGATPATAAATRAFLDSFALVPLDAPVAERAVAVRQAL
RVKLPDAIIKASAEVQGRLLVTRNTRDFPVDDAGVRLPYRL

Nucleotide

• Length: 366 bp

>T116395 NZ_CP034688:4871132-4871497 [Pseudomonas citronellolis]
ATGGTGAAGGCGCTGTTCGACACCAACATCCTCATCGACTACCTCAACGGCCACGAGCAGGCCCGCGACGAGCTGCGCCG
CTACGATGACCCCGCCATCAGCATCGTCACCTGGATGGAGGTGATGATCGGCGCCACGCCCGCCACCGCCGCGGCCACCC
GCGCCTTCCTCGACAGCTTCGCCCTGGTGCCGCTCGACGCGCCCGTCGCCGAGCGCGCCGTGGCGGTGCGCCAGGCGCTG
CGGGTGAAGCTGCCGGACGCCATCATCAAGGCCAGCGCCGAGGTGCAGGGGCGCCTCCTGGTCACCCGCAACACCAGGGA
CTTCCCCGTCGACGACGCCGGCGTGCGCCTGCCCTACCGGCTCTGA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8063.96 Da
• Isoelectric Point: 4.7616

>AT116395 WP_253392721.1 NZ_CP034688:4870923-4871138 [Pseudomonas citronellolis]
MRTLVDIPAEHLEALNTLGEQQQQSRAALIREAVAEYLVRHRRQDAEAAFGLWNGSAGDGLAYQEKVREEW

Nucleotide

• Length: 216 bp

>AT116395 NZ_CP034688:4870923-4871138 [Pseudomonas citronellolis]
ATGCGTACCTTGGTCGACATCCCCGCCGAACACCTGGAGGCGCTCAATACCTTGGGCGAGCAACAGCAGCAATCGCGCGC
CGCGCTGATCCGCGAGGCGGTCGCCGAGTACCTGGTCCGGCACCGCCGGCAGGATGCCGAAGCCGCCTTCGGCCTGTGGA
ACGGCAGCGCCGGCGACGGCCTGGCCTACCAGGAGAAGGTGCGCGAGGAATGGTGA

Structures

Toxin

• AlphaFold DB: A0A1S1GEF4