Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 3866769..3867274 Replicon chromosome
Accession NZ_CP034688
Organism Pseudomonas citronellolis strain WXP-4

Toxin (Protein)


Gene name parE Uniprot ID W5IQ81
Locus tag ELR50_RS17255 Protein ID WP_009614629.1
Coordinates 3866993..3867274 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID W5IQE2
Locus tag ELR50_RS17250 Protein ID WP_009614631.1
Coordinates 3866769..3866996 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELR50_RS17230 (ELR50_17155) 3863390..3863791 - 402 WP_269961923.1 GFA family protein -
ELR50_RS17235 (ELR50_17160) 3863803..3864534 - 732 WP_269961924.1 phytanoyl-CoA dioxygenase family protein -
ELR50_RS17240 (ELR50_17165) 3864531..3865457 - 927 WP_269961925.1 LysR family transcriptional regulator -
ELR50_RS17245 (ELR50_17170) 3865532..3866488 - 957 WP_269961926.1 agmatinase -
ELR50_RS17250 (ELR50_17175) 3866769..3866996 + 228 WP_009614631.1 CopG family ribbon-helix-helix protein Antitoxin
ELR50_RS17255 (ELR50_17180) 3866993..3867274 + 282 WP_009614629.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELR50_RS17260 (ELR50_17185) 3867534..3868244 + 711 WP_269961927.1 RcnB family protein -
ELR50_RS17265 (ELR50_17190) 3868285..3868566 - 282 WP_009614626.1 DUF2218 domain-containing protein -
ELR50_RS17270 (ELR50_17195) 3868664..3869581 + 918 WP_043312499.1 LysR family transcriptional regulator -
ELR50_RS17275 (ELR50_17200) 3869640..3870095 + 456 WP_043312502.1 GNAT family N-acetyltransferase -
ELR50_RS17280 (ELR50_17205) 3870092..3870709 - 618 WP_043312505.1 DUF1826 domain-containing protein -
ELR50_RS17285 (ELR50_17210) 3870709..3871911 - 1203 WP_043312509.1 zinc metallochaperone GTPase ZigA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10251.74 Da        Isoelectric Point: 6.4614

>T116394 WP_009614629.1 NZ_CP034688:3866993-3867274 [Pseudomonas citronellolis]
MSLQWTHKAAADLDGLYDHYVVLIGPEKALKAIQDVVGQVKALADLSLSSVGRPSEVPGVRELPLERWPYQAAYRVKGRD
VQILRIDSVDNPG

Download         Length: 282 bp

>T116394 NZ_CP034688:3866993-3867274 [Pseudomonas citronellolis]
ATGAGCCTGCAGTGGACGCACAAGGCGGCGGCCGACCTGGACGGCCTGTACGACCACTACGTGGTGCTGATCGGCCCGGA
GAAGGCGCTGAAGGCCATCCAGGACGTGGTCGGCCAGGTGAAGGCGCTGGCCGACCTCAGCCTGAGCAGCGTCGGCCGGC
CCAGCGAGGTGCCCGGCGTGCGCGAATTGCCGCTGGAACGCTGGCCCTACCAGGCCGCCTACCGGGTAAAAGGCCGCGAT
GTACAAATTTTGCGCATCGATTCTGTGGATAACCCGGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8357.42 Da        Isoelectric Point: 6.6405

>AT116394 WP_009614631.1 NZ_CP034688:3866769-3866996 [Pseudomonas citronellolis]
MTTVISFRADDALAKALDQLARATHRDRPYHLRQALAQYLERQSWHVAAIDEGLADANAGHLLPHAEIEAKWGLA

Download         Length: 228 bp

>AT116394 NZ_CP034688:3866769-3866996 [Pseudomonas citronellolis]
TTGACCACCGTAATCTCCTTCCGCGCCGATGACGCCCTGGCCAAGGCCCTGGACCAGCTGGCCCGGGCCACCCACCGGGA
CCGCCCCTACCACCTGCGCCAGGCCCTGGCGCAGTACCTGGAGCGCCAGAGCTGGCACGTGGCGGCCATCGACGAGGGCC
TGGCCGACGCCAATGCCGGGCACCTGCTGCCGCACGCCGAGATAGAAGCCAAGTGGGGGCTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A5D1B8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1GJG7

References