Detailed information of TA system TA116391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2871422..2871891
• Replicon: chromosome
• Accession: NZ_CP034688
• Organism: Pseudomonas citronellolis strain WXP-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ELR50_RS12690
• Protein ID: WP_024128153.1
• Coordinates: 2871616..2871891 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W5IQM6
• Locus tag: ELR50_RS12685
• Protein ID: WP_009617620.1
• Coordinates: 2871422..2871616 (+)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELR50_RS12660 (ELR50_12585)	2866460..2868163	+	1704	WP_269964080.1	type IV-A pilus assembly ATPase PilB	-
ELR50_RS12665 (ELR50_12590)	2868167..2869384	+	1218	WP_269964081.1	type II secretion system F family protein	-
ELR50_RS12670 (ELR50_12595)	2869387..2870259	+	873	WP_269964082.1	A24 family peptidase	-
ELR50_RS12675 (ELR50_12600)	2870333..2870941	+	609	WP_009617624.1	dephospho-CoA kinase	-
ELR50_RS12680 (ELR50_12605)	2870938..2871147	+	210	WP_116422665.1	DNA gyrase inhibitor YacG	-
ELR50_RS12685 (ELR50_12610)	2871422..2871616	+	195	WP_009617620.1	hypothetical protein	Antitoxin
ELR50_RS12690 (ELR50_12615)	2871616..2871891	+	276	WP_024128153.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
ELR50_RS12695 (ELR50_12620)	2871898..2872113	-	216	WP_043272266.1	hypothetical protein	-
ELR50_RS12700 (ELR50_12625)	2872221..2872937	-	717	WP_269964083.1	energy-coupling factor ABC transporter permease	-
ELR50_RS12705 (ELR50_12630)	2872934..2873410	-	477	WP_269964084.1	FAD/FMN-containing dehydrogenase	-
ELR50_RS12710 (ELR50_12635)	2873413..2873814	-	402	WP_269964085.1	GNAT family N-acetyltransferase	-
ELR50_RS12715 (ELR50_12640)	2873947..2874576	+	630	WP_009617612.1	DUF1780 domain-containing protein	-
ELR50_RS12720 (ELR50_12645)	2874646..2874819	+	174	WP_009617611.1	DUF3094 family protein	-
ELR50_RS12725 (ELR50_12650)	2874866..2876164	+	1299	WP_269964086.1	NAD(P)/FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10478.03 Da
• Isoelectric Point: 7.3551

>T116391 WP_024128153.1 NZ_CP034688:2871616-2871891 [Pseudomonas citronellolis]
VLSIIWRRSASDDLATILAYIANEDPQAARRLKERVESAVLPLAQHPYLYRHGRVPGTREVVIHPNYILVYRIDAECIEV
VSVLHSRQEYP

Nucleotide

• Length: 276 bp

>T116391 NZ_CP034688:2871616-2871891 [Pseudomonas citronellolis]
GTGCTATCGATCATCTGGCGCAGGAGTGCCAGTGATGACCTCGCGACCATTCTCGCCTATATAGCCAACGAGGATCCCCA
AGCAGCAAGGCGCCTCAAGGAACGCGTGGAGTCTGCCGTGCTGCCGTTGGCCCAGCATCCCTACCTTTACCGTCATGGAC
GAGTACCCGGCACACGAGAAGTCGTGATCCACCCCAACTACATCCTGGTTTACCGGATCGACGCTGAATGCATCGAAGTA
GTCAGCGTCCTGCATTCGCGCCAGGAATATCCCTGA

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7293.07 Da
• Isoelectric Point: 4.9890

>AT116391 WP_009617620.1 NZ_CP034688:2871422-2871616 [Pseudomonas citronellolis]
MSARLSPIVSEFETPEQAASHDRWFRQKVQKSLTDNQPGRPHDEVMVDMDAIIAQAEARRQGND

Nucleotide

• Length: 195 bp

>AT116391 NZ_CP034688:2871422-2871616 [Pseudomonas citronellolis]
ATGAGCGCCCGACTTTCCCCCATCGTCTCCGAGTTCGAAACCCCGGAGCAGGCAGCCAGCCATGATCGCTGGTTCCGCCA
AAAGGTGCAGAAGTCCCTTACAGACAACCAACCAGGGCGTCCCCATGACGAGGTAATGGTCGACATGGACGCCATCATTG
CCCAGGCCGAAGCCCGGCGCCAGGGCAACGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A1A5D6N4