116381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 2004221..2004930 Replicon chromosome
Accession NZ_CP034683
Organism Rheinheimera sp. LHK132

Toxin (Protein)


Gene name dhiT Uniprot ID -
Locus tag EK374_RS09035 Protein ID WP_206099318.1
Coordinates 2004221..2004430 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID -
Locus tag EK374_RS09040 Protein ID WP_127022216.1
Coordinates 2004424..2004930 (+) Length 169 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EK374_RS09015 1999821..2000987 + 1167 WP_127022207.1 ADP-forming succinate--CoA ligase subunit beta -
EK374_RS09020 2000998..2001870 + 873 WP_127022210.1 succinate--CoA ligase subunit alpha -
EK374_RS09025 2002446..2002775 + 330 WP_127022213.1 hypothetical protein -
EK374_RS09030 2003020..2004036 - 1017 WP_127019137.1 IS110 family transposase -
EK374_RS09035 2004221..2004430 + 210 WP_206099318.1 DUF4160 domain-containing protein Toxin
EK374_RS09040 2004424..2004930 + 507 WP_127022216.1 DUF2442 domain-containing protein Antitoxin
EK374_RS09045 2004968..2006074 - 1107 WP_127022219.1 SGNH/GDSL hydrolase family protein -
EK374_RS09050 2006385..2006702 + 318 WP_127022222.1 antibiotic biosynthesis monooxygenase -
EK374_RS09055 2006778..2007176 + 399 WP_127022225.1 fosfomycin resistance glutathione transferase -
EK374_RS09060 2007190..2007330 + 141 WP_127022228.1 DUF2200 family protein -
EK374_RS09065 2007501..2008157 + 657 WP_127022232.1 HAD family hydrolase -
EK374_RS09070 2008283..2008636 + 354 WP_127022235.1 hypothetical protein -
EK374_RS09075 2008778..2009491 + 714 WP_127022238.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(4-51)

Antitoxin

Uncharacterized protein HI1420

(32-165)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.12 Da        Isoelectric Point: 8.0518

>T116381 WP_206099318.1 NZ_CP034683:2004221-2004430 [Rheinheimera sp. LHK132]
MPDLHVKYGSYELIIGIETGESLEGYLPNKQRKRAESHIAEHRQQLMLMWQKAVIGKKTGKLEDMGGVC

Download         Length: 210 bp

>T116381 NZ_CP034683:2004221-2004430 [Rheinheimera sp. LHK132]
TTGCCAGATCTGCATGTTAAATATGGCAGTTATGAACTGATCATCGGTATTGAAACAGGTGAAAGTCTGGAAGGGTATTT
ACCCAATAAACAGCGTAAAAGAGCGGAAAGTCATATCGCTGAGCATCGGCAACAATTGATGCTGATGTGGCAAAAAGCAG
TTATTGGCAAAAAAACCGGCAAGTTAGAAGATATGGGTGGTGTATGTTAA

Antitoxin


Download         Length: 169 a.a.        Molecular weight: 18709.27 Da        Isoelectric Point: 6.4929

>AT116381 WP_127022216.1 NZ_CP034683:2004424-2004930 [Rheinheimera sp. LHK132]
MLKVIDVEWIGDHKLELTFNDGYQGQADLSLYFSKAPFAEILDFKKFSLTADGSLNWSGKELSAATLRAITQGEHKTLET
SFDVKEMETVIKQASWDSMQEGRPDILQAAVRSYVEQFGHSQVIAKAGIKSRTSAYRSLKPETTPNFATLVQLGHAVIEL
AKDKLKQA

Download         Length: 507 bp

>AT116381 NZ_CP034683:2004424-2004930 [Rheinheimera sp. LHK132]
ATGTTAAAAGTCATAGATGTAGAGTGGATTGGCGACCATAAACTTGAGTTGACCTTTAACGACGGCTATCAGGGGCAGGC
TGATTTGTCGTTGTATTTCAGCAAAGCACCATTCGCGGAGATTTTAGACTTTAAGAAGTTCTCTTTAACCGCTGACGGCT
CATTAAACTGGAGTGGCAAAGAGTTATCTGCTGCGACATTGCGGGCTATCACCCAAGGCGAGCACAAAACTTTAGAGACC
AGCTTTGATGTCAAAGAGATGGAAACTGTGATTAAACAGGCGTCATGGGATTCGATGCAGGAAGGGCGTCCTGATATTTT
GCAGGCTGCTGTTCGCTCTTACGTCGAGCAATTTGGTCATAGCCAGGTTATTGCCAAAGCAGGTATTAAAAGCCGAACCA
GTGCTTATCGCTCCTTAAAGCCAGAAACCACACCCAATTTTGCCACTCTGGTGCAGCTGGGTCATGCTGTGATTGAGCTG
GCCAAAGATAAGTTAAAACAAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References