Detailed information of TA system TA116380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1421458..1422002
• Replicon: chromosome
• Accession: NZ_CP034683
• Organism: Rheinheimera sp. LHK132

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EK374_RS06450
• Protein ID: WP_127021223.1
• Coordinates: 1421727..1422002 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EK374_RS06445
• Protein ID: WP_206099351.1
• Coordinates: 1421458..1421727 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EK374_RS06445	1421458..1421727	+	270	WP_206099351.1	ribbon-helix-helix protein, CopG family	Antitoxin
EK374_RS06450	1421727..1422002	+	276	WP_127021223.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EK374_RS06460	1423562..1424185	-	624	WP_127021225.1	TetR/AcrR family transcriptional regulator	-
EK374_RS06465	1424468..1424797	-	330	WP_127026467.1	DoxX family protein	-
EK374_RS06470	1425385..1425735	+	351	WP_164731832.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10868.74 Da
• Isoelectric Point: 9.9882

>T116380 WP_127021223.1 NZ_CP034683:1421727-1422002 [Rheinheimera sp. LHK132]
MELKWTSKALSDLARLYEFLAPENKQAAAKTVLSLIKAPTLLLTNPRIGEQLFEFLPREVRRLLVGHFEMRYELQQQTIY
ILRLWHTREER

Nucleotide

• Length: 276 bp

>T116380 NZ_CP034683:1421727-1422002 [Rheinheimera sp. LHK132]
ATGGAATTGAAGTGGACCAGTAAAGCATTGTCGGATTTAGCCCGACTTTACGAATTTCTGGCTCCGGAAAATAAACAGGC
GGCCGCCAAAACAGTACTAAGTTTGATCAAAGCACCCACACTATTACTGACTAATCCGCGTATAGGCGAGCAGTTATTCG
AGTTTTTACCGCGAGAAGTGAGGCGATTATTAGTAGGGCATTTTGAGATGCGCTACGAACTCCAGCAGCAGACCATTTAT
ATATTGCGGCTTTGGCATACAAGAGAAGAGCGCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9812.07 Da
• Isoelectric Point: 4.4915

>AT116380 WP_206099351.1 NZ_CP034683:1421458-1421727 [Rheinheimera sp. LHK132]
VAQAGTKVLTAHIPLPLAEKVDQMAERLERSRGWIMKQALSAWLEQEEERERLTREALADVDAGQVIDHQAVQAWAESLG
TDNPLAVPG

Nucleotide

• Length: 270 bp

>AT116380 NZ_CP034683:1421458-1421727 [Rheinheimera sp. LHK132]
GTGGCACAAGCCGGAACTAAAGTGTTAACCGCACATATCCCGTTGCCGTTGGCTGAAAAAGTTGACCAAATGGCTGAACG
CTTAGAGCGCTCCCGCGGTTGGATTATGAAACAAGCTTTATCTGCCTGGCTGGAACAGGAAGAAGAGCGCGAACGCTTAA
CTCGTGAAGCTTTGGCAGATGTAGATGCAGGGCAGGTGATCGATCATCAGGCTGTGCAGGCATGGGCCGAAAGCTTAGGC
ACAGATAACCCGTTAGCGGTGCCAGGCTAA