Detailed information of TA system TA116376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4534050..4534566
• Replicon: chromosome
• Accession: NZ_CP034678
• Organism: Klebsiella quasipneumoniae strain D120-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ELE18_RS23250
• Protein ID: WP_048294066.1
• Coordinates: 4534050..4534334 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: ELE18_RS23255
• Protein ID: WP_002886901.1
• Coordinates: 4534324..4534566 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ELE18_RS23235	4529092..4530747	+	1656	WP_127113906.1	alpha,alpha-phosphotrehalase	-
ELE18_RS23240	4531133..4533271	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
ELE18_RS23245	4533582..4534046	+	465	WP_032456904.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
ELE18_RS23250	4534050..4534334	-	285	WP_048294066.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ELE18_RS23255	4534324..4534566	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ELE18_RS23260	4534644..4536554	-	1911	WP_048294065.1	BglG family transcription antiterminator	-
ELE18_RS23265	4536577..4537728	-	1152	WP_057212389.1	lactonase family protein	-
ELE18_RS23270	4537796..4538536	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11141.99 Da
• Isoelectric Point: 10.3787

>T116376 WP_048294066.1 NZ_CP034678:c4534334-4534050 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQKLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T116376 NZ_CP034678:c4534334-4534050 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTGCCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGCTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT116376 WP_002886901.1 NZ_CP034678:c4534566-4534324 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT116376 NZ_CP034678:c4534566-4534324 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGATGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGCGATG
GCGAAGCGGCGTTGTTACGCACCGTTCGCGAGCGGCTGGAAAACCCGCGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0